1. Metabolite predictability across metabolic categories (A) and disease states (B) in the vaginal microbiome.
Metabolite predictability across metabolic categories (A) and disease states (B) in the vaginal microbiome. Well-predicted metabolites are defined as those for which variation in CMP scores is significantly correlated (using a Mantel test) with variation in measured metabolite abundance at a false discovery rate (FDR) of Anti-predicted metabolites are similarly defined as those for which variation in CMP scores is significantly negatively correlated with variation in measured metabolite abundances (FDR 0.01). Metabolic categorization is based on KEGG data, and disease enrichment is based on a Wilcoxon rank sum test for association with bacterial vaginosis (BV) with a Bonferroni-corrected P value of <0.1.
Cecilia Noecker et al. mSystems 2016; doi: /mSystems