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Fructose-1,6-bisphosphate for improved outcome after hypothermic circulatory arrest in pigs  Pekka Romsi, MDa, Timo Kaakinen, MSa, Kai Kiviluoma, MD,

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Presentation on theme: "Fructose-1,6-bisphosphate for improved outcome after hypothermic circulatory arrest in pigs  Pekka Romsi, MDa, Timo Kaakinen, MSa, Kai Kiviluoma, MD,"— Presentation transcript:

1 Fructose-1,6-bisphosphate for improved outcome after hypothermic circulatory arrest in pigs 
Pekka Romsi, MDa, Timo Kaakinen, MSa, Kai Kiviluoma, MD, PhDb, Vilho Vainionpää, MD, PhDb, Jorma Hirvonen, MD, PhDc, Matti Pokela, MSa, Pasi Ohtonen, MSca, Fausto Biancari, MD, PhDa, Matti Nuutinen, MD, PhDd, Tatu Juvonen, MD, PhDa  The Journal of Thoracic and Cardiovascular Surgery  Volume 125, Issue 3, Pages (March 2003) DOI: /mtc Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

2 Fig. 1 Intracerebral temperatures in pigs during experimental protocol in FDP (squares) and control (circles) groups. Data points represent medians; error bars represent interquartile ranges (25th-75th percentile). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

3 Fig. 2 Daily scores from each animal in FDP (A) and control (B) groups indicating behavioral recovery after 75 minutes of HCA. Score of 9 indicates essentially complete recovery. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

4 Fig. 3 Electrolytes and osmolarity in FDP (squares) and control (circles) groups. Data points represent medians; error bars represent interquartile ranges (25th-75th percentile). Asterisk indicates P <.05 for interaction between time versus baseline and other intervals in study groups; double asterisk indicates P <.01 for interaction between time versus baseline and other intervals in study groups. A, Osmolarity; B, venous sodium; C, venous phosphate; D, venous ionized calcium. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

5 Fig. 4 Results of brain microdialysis and intracranial pressure measurements in FDP (squares) and control (circles) groups. Data points represent medians; error bars represent interquartile ranges (25th-75th percentile). P values represent interaction between time versus baseline and other intervals in study groups. A, Brain glucose; B, brain lactate; C, brain pyruvate; D, brain glutamate; E, brain glycerol; F, intracranial pressure. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

6 Fig. 5 EEG burst recovery in pigs after 75 minutes of HCA in FDP (squares) and control (circles) groups. Burst-suppression ratio = [EEG burst time/(EEG burst time + EEG suppression time)] × 100. Data points represent medians; error bars represent interquartile ranges (25th-75th percentile). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

7 Fig. 6 Total brain histopathologic scores from each animal. Higher score indicates more severe brain ischemic injury. Filled circles represent animals alive on postoperative day 7; open circles represent animals dead before postoperative day 7; horizontal lines indicate mean scores. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions


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