1. New insights into the pathogenesis of proteinuria
Richard J. Johnson, MD 
American Journal of Kidney Diseases 
Volume 36, Issue 1, Pages (July 2000)
DOI: /ajkd
Copyright © 2000 National Kidney Foundation, Inc Terms and Conditions

2. Fig 1
Proposed slit diaphragm morphology and structure. In the original paper by Rodewald and Karnovsky,4 the slit diaphragm was shown to be a zipper-like structure by electron micrography (A) and was postulated to be approximately 39 nm in width with a central filament and flanking crossbridges with intervening 4 × 14 nm pores (B). As proposed by Tryggvasson,23 the new molecular model for the slit diaphragm consists of nephrin molecules from opposing foot processes interdigitating their Ig repeats 1 through 6, thus forming the central zipper-like structure observed in the electron microscopy studies (C). The X marks the position of a possible site for an anchoring protein for the nephrin molecule. (Reprinted with permission from Rodewald and Karnovsky4 [A, B] and Tryggvasson23 [C]. [A] and [B] are reproduced from The Journal of Cell Biology , 1974, vol. 60, pp , by copyright permission of The Rockefeller University Press.)
American Journal of Kidney Diseases  , DOI: ( /ajkd )
Copyright © 2000 National Kidney Foundation, Inc Terms and Conditions