1. Hypercholesterolemia

2. Morning Work Outs
Proven to be a fat killer – carb reserves in muscles are nearly empty in the morning, causing body to burn fat for energy
Morning work outs help people burn fat all day long
The body produces “feel good” hormones when exercising which make you less stressful during day and more confident
Jump starts metabolism
Helps you sleep which also helps with weight loss

3. Ways to Increase HDL
Drink OJ – drinking 3 cups of OJ increases HDL by 21%
Replace saturated fats with monounsaturated fats (liquids at room temp)
Substitute soy products for animal-based products
Drink alcohol only in moderation
Moderately intense exercise at least 30 minutes everyday
Don’t smoke
Maintain proper weight

4. Familial Hypercholesterolemia
This is an autosomal dominant disorder
Affects 1 in 500 people in most countries
Men with this have a 50% of a heart attack by age 50 and women 30% by age 60
A person can have heterozygous FH (Ff) or homozygous FH (FF)
Heterozygous can be treated with statins
Statins cause the liver to produce more LDL receptors which pulls LDL out of blood system
Homozygous is harder to treat
LDL receptors are minimally functional
People with this need high doses of statins and this only modestly effects LDL levels
A process similar to dialysis may be used to filter LDL
Severe cases may need a liver transplant

5. How is FH detected? DNA is obtained from patient’s blood or saliva
The section of DNA that contains the LDL receptor gene is amplified by PCR (polymerase chain reactions)
These segments are cut into smaller pieces by restriction enzymes
This is allowed because of RFLP (restriction fragment length polymorphism)
These different lengths are used for comparison in gel electrophoresis

6. Procedure Number 2 Man with FH – Ff Woman w/out - ff F f f Ff ff f Ff

7. Procedure Number 2 Man with FH – FF Woman w/out - ff F F f Ff Ff f Ff

8. Anna’s Family ff Ff ff Ff Ff Ff FF