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The effect of growth factors, cytokines, and extracellular matrix proteins on fibronectin production in human vascular smooth muscle cells  Terry L. Kaiura,

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Presentation on theme: "The effect of growth factors, cytokines, and extracellular matrix proteins on fibronectin production in human vascular smooth muscle cells  Terry L. Kaiura,"— Presentation transcript:

1 The effect of growth factors, cytokines, and extracellular matrix proteins on fibronectin production in human vascular smooth muscle cells  Terry L. Kaiura, BS, Hiroyuki Itoh, MD, Stephen M. Kubaska, MD, Timothy A. McCaffrey, PhD, Bo Liu, PhD, K.Craig Kent, MD  Journal of Vascular Surgery  Volume 31, Issue 3, Pages (March 2000) DOI: /mva Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 Fibronectin production in quiescent cultured human vascular SMCs after 72 hours of stimulation with increasing concentrations of (A) TGF-β, EGF, collagen type I, and angiotensin II (AT II ) or (B) PDGF-BB, FGF, collagen type IV, and laminin. Fibronectin was assayed in the cell medium with the use of an antibody specific for the 220 kD subunit. All experiments were repeated at least three times, and a representative example is displayed. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Fibronectin production in quiescent cultured human vascular SMCs at 0, 24, 48, and 72 hours after stimulation with TGF-β, EGF, collagen type I, or angiotensin II (AT II ; right panel ) and their respective vehicle controls (left panel ). Fibronectin was assayed in the cell medium with the use of an antibody specific for the 220 kD subunit of fibronectin. All experiments were repeated at least three times, and a representative example of each is displayed. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Fold increase ± SD in fibronectin production in quiescent cultured human vascular SMCs after 72-hour stimulation with TGF-β (10 ng/mL), EGF (100 ng/mL), collagen type I (20 μg/mL), or angiotensin II (AT II ; 100 ng/mL). Fibronectin was assayed in the cell medium with the use of an antibody specific for the 220 kD subunit of fibronectin. All experiments were repeated at least three times. *P <.05 vs control. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

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