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Levels of the retinoic acid synthesizing enzyme aldehyde dehydrogenase-1A2 are lower in testicular tissue from men with infertility  John K. Amory, M.D.,

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Presentation on theme: "Levels of the retinoic acid synthesizing enzyme aldehyde dehydrogenase-1A2 are lower in testicular tissue from men with infertility  John K. Amory, M.D.,"— Presentation transcript:

1 Levels of the retinoic acid synthesizing enzyme aldehyde dehydrogenase-1A2 are lower in testicular tissue from men with infertility  John K. Amory, M.D., M.P.H., Samuel Arnold, M.S., María C. Lardone, M.Sc., Antonio Piottante, M.D., Mauricio Ebensperger, M.D., Nina Isoherranen, Ph.D., Charles H. Muller, Ph.D., Thomas Walsh, M.D., Andrea Castro, M.Sc.  Fertility and Sterility  Volume 101, Issue 4, Pages (April 2014) DOI: /j.fertnstert Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Box and whiskers plots of (A) ALDH1A1, (B) ALDH1A2, and (C) ALDH1A3 from testicular tissue of the men by histologic subtype. Each box represents the median, 25th and 75th percentiles, with the upper and lower values represented by the bars and outliers represented as open circles. The values are expressed relative to the mean of the group of normal men. Therefore, amounts of protein are comparable between the groups of subjects within an assay but not between proteins. **P<.001 compared with normal men; *P<.05 compared with normal men. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Scatter plots of (A) spermatogonia, (B) spermatocytes, and (C) early spermatids versus the ALDH1A2 protein level from testicular tissue of the 43 study participants. Correlations were performed using Spearman’s technique. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions


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