1. Model of the stepwise regulation of localization of GpGCS1 specifically to the minus TMS. The GpGCS1 protein level is enriched in minus gametes by transcriptional regulation (step 1). minus-specific transport to the primordial TMS site (step 2) then enables GpGCS1 to be present on the minus TMS upon activation.
Model of the stepwise regulation of localization of GpGCS1 specifically to the minus TMS. The GpGCS1 protein level is enriched in minus gametes by transcriptional regulation (step 1). minus-specific transport to the primordial TMS site (step 2) then enables GpGCS1 to be present on the minus TMS upon activation. In contrast, GpGCS1 rapidly degrades in plus gametes (step 3).
Hiroko Kawai-Toyooka et al. Eukaryotic Cell 2014; doi: /EC