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“It Is a Good Morning Exercise for a Research Scientist to Discard a Pet Hypothesis Every Day Before Breakfast: It Keeps Him Young” (Konrad Lorenz, 1903–1989) 

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Presentation on theme: "“It Is a Good Morning Exercise for a Research Scientist to Discard a Pet Hypothesis Every Day Before Breakfast: It Keeps Him Young” (Konrad Lorenz, 1903–1989) "— Presentation transcript:

1 “It Is a Good Morning Exercise for a Research Scientist to Discard a Pet Hypothesis Every Day Before Breakfast: It Keeps Him Young” (Konrad Lorenz, 1903–1989)  John P. Iredale, Antonella Pellicoro  Gastroenterology  Volume 140, Issue 5, Pages (May 2011) DOI: /j.gastro Copyright © 2011 AGA Institute Terms and Conditions

2 Figure 1 Myofibroblasts recruited from activated hepatic stellate cells and other elements secrete fibrillar collagens (I and III) and other matrix components in liver fibrosis. LOX and transglutaminases cross-link and stabilize this collagen which concurrently makes it less susceptible to degradation by matrix metalloproteinases and other enzymes. The work presented by Popov et al provides an opportunity to understand the biological role of the ubiquitous TG2. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions


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