1. Association with Genetic Variants in the IL-23 and NF-κB Pathways Discriminates between Mild and Severe Psoriasis Skin Disease 
Pernilla Nikamo, Josefin Lysell, Mona Ståhle 
Journal of Investigative Dermatology 
Volume 135, Issue 8, Pages (August 2015)
DOI: /jid
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
Association of markers analyzed in psoriasis subjects. Stratification of psoriasis patients reveals association in the severe phenotype. Odds ratios for case–control study are shown, and a case–case study exposes distinct genetic profiles in severe versus mild psoriasis. Three of the most significantly associated genes remained significant after correction: IL23R, IL23A, and NFKBIL1 (P<0.05). *P<0.05, **P<0.01, and ***P<0.001.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Additive interaction in severe psoriasis. Calculating biological interaction in severe subjects using R program results showing additive interaction between (a) rs (TNFAIP3) and rs (NFKBIL1), APp 0.001, AP 0.554, 95% CI 0.225–0.883; (b) rs (TNIP1) and rs (NFKBIL1), APp , AP 0.503, 95% CI 0.301–0.705; (c) rs (IL23R) and HLA-C, APp 0.002, AP 0.364, 95% CI 0.133–0.595, as well as (d) rs (NFKB1) and HLA-C, APp , AP 0.541, 95% CI 0.252– Interactions in (b) and (d) remain significant after correction for multiple testing (P<0.05).
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions