1. Chondrocyte catabolic response to synovial fluid obtained from different OA joints: deciphering the roles of TLR4-mediated response 
G. Barreto, D. Nordström, K.K. Eklund 
Osteoarthritis and Cartilage 
Volume 24, (April 2016)
DOI: /j.joca
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2. Figure 1
OA Primary chondrocytes and HEK-hTLR4 cells response to SF obtained from CMC-I and knee OA patients. (A) Several chondrocyte produced catabolic factors are differentially upregulate by OA SF from CMC-I and knee. All molecules were measured in Luminex xMap technology and are expressed in pg/ml (B). OA SF from CMC-I and knee joint fails to activate HEK-hTLR4 reporter cells. Results are represented as mean and SD. All experiments were replicated in three (n>3) independent experiments.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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3. Figure 2
OA primary chondrocyte nitric oxide production and MMP-13 levels LPS-induced levels are inhibited by sTLR4/MD2. (A) Nitric Oxide is upregulated by TLR4 ligands, while sTLR4/MD2 prevent LPS-induce upregulate levels. (B) MMP-13 protein levels upregulation by LPS is inhibited by sTLR4/MD2. Results are represented as mean and SD. All experiments were replicated in at least three (n>3) independent experiments.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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