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An Evidence-based Review of Anti-CD20 Antibody-containing Regimens for the Treatment of Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia,

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Presentation on theme: "An Evidence-based Review of Anti-CD20 Antibody-containing Regimens for the Treatment of Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia,"— Presentation transcript:

1 An Evidence-based Review of Anti-CD20 Antibody-containing Regimens for the Treatment of Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Diffuse Large B-cell Lymphoma, or Follicular Lymphoma  Lorenzo Falchi, Alessandra Ferrajoli, Ira Jacobs, Pilar Nava-Parada  Clinical Lymphoma, Myeloma and Leukemia  Volume 18, Issue 8, Pages e14 (August 2018) DOI: /j.clml Copyright © 2018 Elsevier Inc. Terms and Conditions

2 Figure 1 Reported Overall Response Rate (ORR) for Patients With Relapsed or Refractory (A) Chronic Lymphocytic Leukemia (CLL), (B) Follicular Lymphoma (FL), or (C) Diffuse Large B-cell Lymphoma (DLBCL). Data Points Represent Reported ORR for Each Study, Stratified by Drug Regimen and Median Patient Age. ORR Data Were Reported in 25 Studies for Rituximab Across All 3 Diseases, 10 Studies for Ofatumumab, and 1 Study for Obinutuzumab. Several Studies Reported Data for > 1 Anti-CD20 Combination or Disease. Thus, the Data Points Will Not Correspond to the Total Number of Studies Reporting ORR Data Abbreviations: B = bendamustine; B-Ibr = bendamustine, ibrutinib; B-idela = bendamustine, idelalisib; CHOP = cyclophosphamide, doxorubicin, vincristine, prednisolone; Clb = chlorambucil; Dex = dexamethasone; DHAP = dexamethasone, high-dose cytarabine, cisplatin; ESHAP = etoposide, methylprednisolone, cytarabine, cisplatin; F = fludarabine; FC = fludarabine, cyclophosphamide; FCM = fludarabine, cyclophosphamide, mitoxantrone; FM = fludarabine, mitoxantrone; Ibr = ibrutinib; ICE = ifosfamide, carboplatin, etoposide; Idela = idelalisib; Ven = venetoclax. Clinical Lymphoma, Myeloma and Leukemia  , e14DOI: ( /j.clml ) Copyright © 2018 Elsevier Inc. Terms and Conditions


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