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Characteristics and Outcomes of Patients with Lung Cancer Harboring Multiple Molecular Alterations: Results from the IFCT Study Biomarkers France  Nicolas.

Published byMarie-Laure Adélaïde Bessette Modified over 5 years ago

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Presentation on theme: "Characteristics and Outcomes of Patients with Lung Cancer Harboring Multiple Molecular Alterations: Results from the IFCT Study Biomarkers France  Nicolas."— Presentation transcript:

1 Characteristics and Outcomes of Patients with Lung Cancer Harboring Multiple Molecular Alterations: Results from the IFCT Study Biomarkers France  Nicolas Guibert, MD, Fabrice Barlesi, MD, PhD, Renaud Descourt, MD, Hervé Léna, MD, Benjamin Besse, MD, PhD, Michèle Beau- Faller, MD, PhD, Jean Mosser, MD, PhD, Eric Pichon, MD, Jean-Philippe Merlio, MD, PhD, L'Houcine Ouafik, MD, PhD, François Guichard, MD, Bénédicte Mastroianni, MD, Lionel Moreau, MD, Annie Wdowik, MD, Jean-Christophe Sabourin, MD, Antoinette Lemoine, MD, PhD, Pascale Missy, PhD, Alexandra Langlais, MSc, Denis Moro-Sibilot, MD, PhD, Julien Mazières, MD, PhD  Journal of Thoracic Oncology  Volume 12, Issue 6, Pages (June 2017) DOI: /j.jtho Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Overall survival (OS) in the presence of double mutation involving EGFR compared to EGFR mutated patients. (A) OS in patients harboring double mutation involving EGFR (EGFR+X) compared to EGFR mutated patients. (B) OS in the presence of EGFR and PI3K co-mutation compared to EGFR mutated patients. (C) OS in the presence of EGFR and ALK co-mutation compared to EGFR mutated patients. (D) OS in the presence of EGFR and KRAS co-mutation compared to EGFR mutated patients. IC95%, concentration that inhibits 95%; HR, hazard ratio; NR, not reached. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Progression-free survival (PFS) in the presence of double mutation involving EGFR compared to EGFR mutated patients. (A) PFS in the whole population of patients harboring double mutation involving EGFR (EGFR+X) compared to EGFR mutated patients. (B) PFS in the presence of EGFR and PI3K co-mutation compared to EGFR mutated patients. (C) PFS in the presence of EGFR and ALK co-mutation compared to EGFR mutated patients. (D) PFS in the presence of EGFR and KRAS co-mutation compared to EGFR mutated patients. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Response to targeted therapies in the presence of a double mutation compared to a single mutation. (A) Response to first-line treatment by EGFR-TKIs in patients harboring double mutation involving EGFR (EGFR+X) compared to EGFR mutated patients. (B) Response to second-line treatment by EGFR-TKIs in patients harboring double mutation involving EGFR (EGFR+X) compared to EGFR mutated patients. (C) Response to EGFR-TKIs in the presence of EGFR and PI3K co-mutation compared to EGFR mutated patients. (D) Response to crizotinib in patients harboring double molecular alterations involving ALK rearrangement (ALK+X) compared to ALK patients. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

5 Figure 4 Response to chemotherapy in the presence of a double mutation including KRAS compared to KRAS mutated patients. (A) Response to chemotherapy in patients harboring double mutation involving KRAS (KRAS+X) compared to KRAS mutated patients. (B) Response to chemotherapy in the presence of KRAS and EGFR co-mutation compared to KRAS mutated patients. (C) Response to chemotherapy in the presence of KRAS mutation and ALK rearrangement compared to KRAS mutated patients. (D) Response to chemotherapy in the presence of KRAS and PI3K co-mutation compared to KRAS mutated patients. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

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