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Balancing Life and Death in the Ischemic Brain: SIK and TORC Weigh In

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Presentation on theme: "Balancing Life and Death in the Ischemic Brain: SIK and TORC Weigh In"— Presentation transcript:

1 Balancing Life and Death in the Ischemic Brain: SIK and TORC Weigh In
Eduardo F. Gallo, Costantino Iadecola  Neuron  Volume 69, Issue 1, Pages 3-6 (January 2011) DOI: /j.neuron Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 SIK2 Degradation Provides Neuroprotection after Ischemia
According to Sasaki et al., ischemic neurons utilize a previously unrecognized cytoprotective pathway involving CREB activation through CaMK I/IV, SIK2, and TORC1 (left), which attempts to counterbalance the deleterious consequences of NMDAR overactivation (right). Neuron  , 3-6DOI: ( /j.neuron ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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