1. Mast cell granules: Modulating adaptive immune response remotely
Rohit Jain, PhD, Shweta Tikoo, PhD, Wolfgang Weninger, MD 
Journal of Allergy and Clinical Immunology 
Volume 143, Issue 5, Pages (May 2019)
DOI: /j.jaci
Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
Schematic representation of MCG-mediated modulation of adaptive immune responses. A, After noxious stimuli, mast cells degranulate and release their contents into the extracellular space. Mast cell–derived TNF aids in uptake of MCGs by CD103+CD11b− DCs. B, Phagocytosis of intact MCGs by DDCs results in enhanced expression of lymph node homing receptor CCR7 and costimulatory molecules, such as CD80/86, leading to DC maturation and egress from the cutaneous tissue. C, During the early phase of the response, these MCG-bearing DCs present antigens to CD4+ and CD8+ T cells, leading to their subsequent expansion. PAMPs/DAMPs, Pathogen-associated molecularpatterns/damage-associated molecular patterns.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions