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Volume 40, Issue 1, Pages (January 2004)

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Presentation on theme: "Volume 40, Issue 1, Pages (January 2004)"— Presentation transcript:

1 Volume 40, Issue 1, Pages 184-186 (January 2004)
Protease inhibitors for treatment of chronic hepatitis C—a new target for the magic bullet identified  Peter Ferenci  Journal of Hepatology  Volume 40, Issue 1, Pages (January 2004) DOI: /j.jhep

2 Fig. 1 Simplified scheme of activation of type I interferons (IFNs) by viral infections. HCVs like most viruses have evolved strategies to block and interfere with the IFN pathway. (1) Blocking of IFN induction/expression by a serine protease in the NS3/NS4 region inhibits the activation of IRF-3 [13]. (2) Interaction of PKR with HCV E2 protein abolishes antiviral activity of IFN [3]. Abbreviations: IKK, IκB kinase; IRF, IFN-regulatory factor; ISG, IFN-stimulated genes; JAK, Janus kinase; Mx, myxovirus-resistance proteins; OAS, oligoadenylate synthetase; PKR, IFN-inducible protein kinase; STAT, signal transducer and activator of transcription; TYK, tyrosine kinase. Journal of Hepatology  , DOI: ( /j.jhep )

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