1. Inflammation, ROS, and Mutagenesis
Asmaa El-Kenawi, Brian Ruffell 
Cancer Cell 
Volume 32, Issue 6, Pages (December 2017)
DOI: /j.ccell
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
Myeloid-Cell-Derived ROS Promotes Inflammation and Mutagenesis
(A) During acute inflammation, the production of ROS (such as H2O2) by myeloid cells promotes apoptosis of damaged cells, wound repair and a return to tissue homeostasis.
(B) As a consequence of Gpx4-deficiency in macrophages and/or neutrophils, increased production of extracellular ROS leads to oxidative stress within epithelial cells and the accumulation of oncogenic mutations. ROS production also creates a positive feedback loop via autocrine TNF-α-mediated expression of inflammatory cytokines/chemokines (data not shown), and the combination of these two pathways drives neoplastic progression.
Cancer Cell  , DOI: ( /j.ccell )
Copyright © 2017 Elsevier Inc. Terms and Conditions