1. ZBTB48 is required for MTFP1 expression
ZBTB48 is required for MTFP1 expression Western blot confirmation of reduced MTFP1 expression in each five HeLa and U2OS ZBTB48 KO clones compared to five WT clones each. Similar to ZBTB48, no detectable MTFP1 protein is found in the KO cells.Super‐resolution fluorescence microscopy analysis of the structure and localization of the mitochondrial network in HeLa WT and ZBTB48 KO clones. Mitochondria are marked with the MitoTracker dye (red), and nuclei are counterstained with DAPI (blue). Scale bars represent 5 μm.mtDNA level quantification comparing five HeLa ZBTB48 WT and KO clones. mtDNA levels were quantified based on three mtDNA loci and normalized to two genomic regions. Error bars represent standard deviations (n = 3). The P‐value is based on Student's t‐test.
Arne Jahn et al. EMBO Rep. 2017;embr
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