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Increased nitric oxide levels in exhaled air of rat lung allografts

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1 Increased nitric oxide levels in exhaled air of rat lung allografts
Takatoshi Mizuta, MDa, Yoshitaka Fujii, MDa, Masato Minami, MDa, Satonori Tanaka, MDa, Tomoki Utsumi, MDa, Hiroaki Kosaka, MDb, Ryouta Shirakura, MDc, Hikaru Matsuda, MDa  The Journal of Thoracic and Cardiovascular Surgery  Volume 113, Issue 5, Pages (May 1997) DOI: /S (97) Copyright © 1997 Mosby, Inc. Terms and Conditions

2 Fig. 1 Exhaled NO concentrations from untreated allografts (n = 5), cyclosporine (CsA)-treated allografts (n = 4), and control isografts (n = 4). *Significant difference from untreated allografts on postoperative days (POD) 2 through 4 (p = ) and on day 5 for isografts (p = ) and cyclosporine-treated allografts (p = ). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

3 Fig. 2 Changes in exhaled NO concentrations in untreated (closed circles, n = 4) and cyclosporine (CsA)-treated (open circles, n = 4) allografts before and after the animals were killed. *p = 0.06; **p = 0.07 versus before death. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

4 Fig. 3 Exhaled NO concentrations from right (Rt) and left (Lt) lungs in untreated (solid bars, n = 5) and cyclosporine (CsA)-treated (open bars, n = 4) allografts. *p = ; **p = versus left lungs. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

5 Fig. 4 A, Ventilation scores of untreated (closed circles, n = 5) and cyclosporine-treated (open circles, n = 4) allografts. *p = 0.005; **p = versus day 5 in untreated allografts; ***p = versus day 5 in untreated allografts. pod, Postoperative day. B, No significant correlation was seen between ventilation score and the concentrations of exhaled NO. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

6 Fig. 4 A, Ventilation scores of untreated (closed circles, n = 5) and cyclosporine-treated (open circles, n = 4) allografts. *p = 0.005; **p = versus day 5 in untreated allografts; ***p = versus day 5 in untreated allografts. pod, Postoperative day. B, No significant correlation was seen between ventilation score and the concentrations of exhaled NO. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

7 Fig. 5 A, Histologic rejection grade of untreated (closed circles, n = 5) and cyclosporine-treated (open circles, n = 4) allografts. *p = versus day 3 in untreated allografts. pod, Postoperative day. B, Correlation between rejection grade and the concentrations of exhaled NO. p = with Spearman's correlation coefficient by rank. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

8 Fig. 5 A, Histologic rejection grade of untreated (closed circles, n = 5) and cyclosporine-treated (open circles, n = 4) allografts. *p = versus day 3 in untreated allografts. pod, Postoperative day. B, Correlation between rejection grade and the concentrations of exhaled NO. p = with Spearman's correlation coefficient by rank. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

9 Fig. 6 Serum nitrite/nitrate concentrations in untreated allografts (n = 5), cyclosporine (CsA)-treated allografts (n = 4), and control isografts (n = 4). There were no significant differences among groups. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions


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