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Immigrating progenitor cells contribute to human podocyte turnover

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Presentation on theme: "Immigrating progenitor cells contribute to human podocyte turnover"— Presentation transcript:

1 Immigrating progenitor cells contribute to human podocyte turnover
J.U. Becker, A. Hoerning, K.W. Schmid, P.F. Hoyer  Kidney International  Volume 72, Issue 12, Pages (December 2007) DOI: /sj.ki Copyright © 2007 International Society of Nephrology Terms and Conditions

2 Figure 1 Recipient-derived podocyte from patient, biopsy 2.1, female donor, and male recipient. A recipient-derived podocyte (small frame) can be recognized by the presence of a Y chromosome (green) in a WT-1-positive (red) podocyte nucleus. X chromosomes are also marked in red; nuclei are marked in blue. The inset in the top right corner shows details from the corresponding small frame. Combined FISH for X- and Y chromosomes and IF for WT-1, counterstained with 4′,6′-diamidino-2-phenylindole. Original magnification × 600, oil immersion. 86 × 68 mm (300×300 d.p.i.). Kidney International  , DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions

3 Figure 2 Recipient-derived podocytes from patient 3, biopsy 3.2, female donor, and male recipient. Two recipient-derived podocytes (small frames) can be recognized by the presence of a Y chromosome (green) in a WT-1-positive (red) podocyte nucleus. X chromosomes are also marked in red; nuclei are marked in blue. Insets in the top left and right corner show details from the corresponding small frames. Combined FISH for X- and Y chromosomes and IF for WT-1, counterstained with 4′,6′-diamidino-2-phenylindole. Original magnification: × 600, oil immersion. 86 × 68mm (300 × 300 d.p.i.). Kidney International  , DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions


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