1. Therapeutic Dendritic Cell Vaccination of Patients with Renal Cell Carcinoma 
Annika Berntsen, Poul F. Geertsen, Inge Marie Svane 
European Urology 
Volume 50, Issue 1, Pages (July 2006)
DOI: /j.eururo
Copyright © 2006 European Association of Urology Terms and Conditions

2. Fig. 1
Activation of naïve CD4 or CD8 T cells requires two independent signals. Binding of T-cell receptor (TCR) to the antigen-HLA complex on the dendritic cell (DC) delivers a signal (signal 1) that can induce activation and expansion of T cells when the costimulatory signal (signal 2) is given by binding of CD28 to B7 molecules.
European Urology  , 34-43DOI: ( /j.eururo )
Copyright © 2006 European Association of Urology Terms and Conditions