1. What Lies Beneath: Wnt/β-Catenin Signaling and Cell Fate in the Lower Dermis 
Colin A.B. Jahoda, Adam C. Gilmore 
Journal of Investigative Dermatology 
Volume 136, Issue 6, Pages (June 2016)
DOI: /j.jid
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2. Figure 1
Wnt/β-catenin signaling: a key controller in dermal differentiation and pathophysiology. Mastrogiannaki et al. (2016) provide evidence of overexpressed β-catenin controlling adipogenic differentiation in the reticular dermis. Using previous defined markers (Driskell et al., 2013), the authors selectively target reticular fibroblasts (Pdgfrα+/Dlk1+) to stabilize β-catenin. Overexpression of dermal Wnt/β-catenin negatively regulates adipocyte terminal differentiation, leading to an increase in preadipocytes and a diminished dermal adipose layer. Accompanying the loss of adipocytes was a fibrotic dermal phenotype and a prolongation of the anagen phase of the hair cycle. Pdgfrα+, platelet-derived growth factor receptor–α; Dlk1, delta-like homologue 1; E, embryonic day; Sca1, stem cell antigen 1.
Journal of Investigative Dermatology  , DOI: ( /j.jid )
Copyright © 2016 The Authors Terms and Conditions