1. Treg Cells and CTLA-4: The Ball and Chain of the Germinal Center Response 
Michelle A. Linterman, Alice E. Denton 
Immunity 
Volume 41, Issue 6, Pages (December 2014)
DOI: /j.immuni
Copyright © 2014 Elsevier Inc. Terms and Conditions

2. Figure 1
Treg Cell-Expressed CTLA-4 Controls the Germinal Center from the Outside and Within
Treg-expressed CTLA-4 modulates the size of the GC at two distinct anatomical locations. First, at the border of the B cell follicle where Treg cells can interact with non-GC B cells and limit their expression of CD86. This limited expression of CD86 restricts Tfh differentiation via reduced CD28 signaling. Second, within the GC, Tfr cells may act to directly regulate CD86 expression on B cells or act in a way that is independent of CD86 transendocytosis to limit the amount of CD28 signaling available to GC-Tfh cells.
Immunity  , DOI: ( /j.immuni )
Copyright © 2014 Elsevier Inc. Terms and Conditions