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Alteration of Gastric Functions and Candidate Genes Associated With Weight Reduction in Response to Sibutramine  Maria I. Vazquez Roque, Michael Camilleri,

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Presentation on theme: "Alteration of Gastric Functions and Candidate Genes Associated With Weight Reduction in Response to Sibutramine  Maria I. Vazquez Roque, Michael Camilleri,"— Presentation transcript:

1 Alteration of Gastric Functions and Candidate Genes Associated With Weight Reduction in Response to Sibutramine  Maria I. Vazquez Roque, Michael Camilleri, Matthew M. Clark, Debra A. TePoel, Michael D. Jensen, Karen M. Graszer, Sarah A. Kalsy, Duane D. Burton, Kari L. Baxter, Alan R. Zinsmeister  Clinical Gastroenterology and Hepatology  Volume 5, Issue 7, Pages (July 2007) DOI: /j.cgh Copyright © 2007 AGA Institute Terms and Conditions

2 Figure 1 Trial flow. Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions

3 Figure 2 Gastric emptying of solids and liquids in obese or overweight individuals treated with placebo or sibutramine. Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions

4 Figure 3 Change in body weight in overweight and obese males and females treated with placebo and sibutramine (A). Note the overall significant effects of sibutramine on weight loss are most clearly demonstrable in obese females. Changes in gastric emptying of solids (B) and liquids (C) in overweight and obese males and females treated with placebo and sibutramine. Note that overall significant effects of sibutramine on gastric emptying are most clearly demonstrable in obese females and overweight males. Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions


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