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A Phase II, Open-Label Study of Ramucirumab in Combination with Paclitaxel and Carboplatin as First-Line Therapy in Patients with Stage IIIB/IV Non–Small-Cell.

Published byVerawati Widyawati Lesmana Modified over 5 years ago

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Presentation on theme: "A Phase II, Open-Label Study of Ramucirumab in Combination with Paclitaxel and Carboplatin as First-Line Therapy in Patients with Stage IIIB/IV Non–Small-Cell."— Presentation transcript:

1 A Phase II, Open-Label Study of Ramucirumab in Combination with Paclitaxel and Carboplatin as First-Line Therapy in Patients with Stage IIIB/IV Non–Small-Cell Lung Cancer  D. Ross Camidge, MD, PhD, Eamon M. Berge, MD, Robert C. Doebele, MD, PhD, Marc S. Ballas, MD, Thierry Jahan, MD, Missak Haigentz, MD, David Hoffman, MD, James Spicer, MD, PhD, Howard West, MD, Pablo Lee, MD, Ling Yang, PhD, Adarsh Joshi, PhD, Ling Gao, PhD, Sergey Yurasov, MD, Alain Mita, MD  Journal of Thoracic Oncology  Volume 9, Issue 10, Pages (October 2014) DOI: /JTO Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Kaplan–Meier estimates for PFS (A) and OS (B). CI, confidence interval; mo, months; OS, overall survival; PFS, progression-free survival. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Waterfall plot of best overall percent change from baseline in target lesion measurement (n = 39). Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Biomarker analysis and association with clinical outcomes: association of SNP rs G/G and A/G or A/A with PFS (A), OS (B), and best overall response rate (C) in treated non-Hispanic Caucasian patients in the translational research population with SNP data (n = 21). The median and upper ends of the 95% CI for OS in the patients with A/G or A/A genotype were not estimable. CI, confidence interval; NE, nonestimable; OS, overall survival; PFS, progression-free survival; SNP, single-nucleotide polymorphism. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

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