1. PDE1 predominantly regulates the threshold for RP induction.
PDE1 predominantly regulates the threshold for RP induction. (A) Time courses of amplitude of GABA currents and representative current traces before and after the conditioning depolarization (0 mV for 500 ms, five times at 0.5 Hz) in the absence (control), or presence of AIP‐II or KT5720. n=5 for each. (B–G) Time courses of amplitude of GABA currents before and after conditioning stimulation consisting of five depolarization pulses with duration of 20, 40, 60, 100, or 500 ms in the absence (B, control) or presence of 8‐MM‐IBMX (C), vinpocetine (D), rolipram (E), FK506 (F), or cyclosporine A (G). n=3 for each. Representative current traces before and 30 min after the conditioning stimulation composed of five depolarization pulses with duration of 20, 40, or 500 ms are also shown in each panel. Scale bars indicate 200 pA and 1 s. (H) The relationship between the strength of conditioning stimulation (duration of each depolarization pulse) and the extent of GABA response potentiation at 30 min. PDE1 inhibition by either 8‐MM‐IBMX or vinpocetine significantly lowered the threshold for RP induction compared with the control (P<0.001, two‐way ANOVA, and Dunnet T3 test).
Yuichi Kitagawa et al. Mol Syst Biol 2009;5:280
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