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Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients  L. Meng, M. Cannesson, B.S. Alexander, Z. Yu,

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Presentation on theme: "Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients  L. Meng, M. Cannesson, B.S. Alexander, Z. Yu,"— Presentation transcript:

1 Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients  L. Meng, M. Cannesson, B.S. Alexander, Z. Yu, Z.N. Kain, A.E. Cerussi, B.J. Tromberg, W.W. Mantulin  British Journal of Anaesthesia  Volume 107, Issue 2, Pages (August 2011) DOI: /bja/aer150 Copyright © 2011 The Author(s) Terms and Conditions

2 Fig 1 Continuous MAP, CO, and SctO2 recordings from two selected patients. (a–c) Recordings during phenylephrine treatment. (d–f) Recordings during ephedrine treatment. Both agents were given during the first treatment. Vertical arrows indicate the drug administration time. British Journal of Anaesthesia  , DOI: ( /bja/aer150) Copyright © 2011 The Author(s) Terms and Conditions

3 Fig 2 Measurements of MAP, CO, and SctO2 for every patient. (a–c) Measurements before (pre) and after (post) phenylephrine treatments. (d–f) Measurements before (pre) and after (post) ephedrine treatments. British Journal of Anaesthesia  , DOI: ( /bja/aer150) Copyright © 2011 The Author(s) Terms and Conditions

4 Fig 3 Grouped MAP (a), CO (b), and SctO2 (c) changes after the first and second phenylephrine (Phe) and the first and second ephedrine (Eph) treatments. The blue bars represent pretreatment values; the green striped bars represent post-treatment values. *P<0.01 (first treatment vs second treatment, unpaired Student's t-test). British Journal of Anaesthesia  , DOI: ( /bja/aer150) Copyright © 2011 The Author(s) Terms and Conditions

5 Fig 4 Pearson's correlations between SctO2 and global haemodynamics (MAP and CO) during the first and second phenylephrine (a and b) and the first and second ephedrine treatments (Tx) (c and d). ▵=post–pre. British Journal of Anaesthesia  , DOI: ( /bja/aer150) Copyright © 2011 The Author(s) Terms and Conditions


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