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D. J. Hunter, N. Arden, F. Cicuttini, M. D. Crema, B. Dardzinski, J

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Presentation on theme: "D. J. Hunter, N. Arden, F. Cicuttini, M. D. Crema, B. Dardzinski, J"— Presentation transcript:

1 OARSI Clinical Trials Recommendations: Hand imaging in clinical trials in osteoarthritis 
D.J. Hunter, N. Arden, F. Cicuttini, M.D. Crema, B. Dardzinski, J. Duryea, A. Guermazi, I.K. Haugen, M. Kloppenburg, E. Maheu, C.G. Miller, J. Martel-Pelletier, R.E. Ochoa-Albíztegui, J.-P. Pelletier, C. Peterfy, F. Roemer, G.E. Gold  Osteoarthritis and Cartilage  Volume 23, Issue 5, Pages (May 2015) DOI: /j.joca Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 Visualization of thumb base OA. A. T1-weighted spin echo MRI shows ulnar-sided osteophytes at the base of the first metacarpal and the articulating os trapezium (arrows). In addition there is subchondral sclerosis ideally visualized on T1-weighted images (arrowhead). B. Corresponding T1-weighted fat-suppressed contrast-enhanced MRI shows concomitant synovitis surrounding the metacarpal osteophyte (black arrow) and subchondral bone marrow lesions (white arrowheads). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

3 Fig. 2 Severe OA of the DIP joints. Coronal T1-weighted MRI shows large osteophytes at the ulnar-sided heads of the second and third middle phalanges. In addition there is a subchondral erosion at the head of fourth middle phalanx visualized as a rounded hypointense lesion on T1-weighted imaging (arrowhead). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

4 Fig. 3 Representative clinical MRI in a person with hand OA. A. Coronal fat-suppressed proton density-weighted MRI reveals a small subchondral cyst in the third PIP joint. B. Coronal T1-weighted MRI depicts small osteophytes, subchondral sclerosis and cartilage loss in multiple joints including thumb IP, second DIP and third PIP joints. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

5 Fig. 4 Quantifying power-Doppler ultrasound over 36 frames of acquisition of the metacarpophalangeal joint. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

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