1. Genome Organization: Cohesin on the Move
Judita Richterova, Barbora Huraiova, Juraj Gregan 
Molecular Cell 
Volume 66, Issue 4, Pages (May 2017)
DOI: /j.molcel
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
Model for Chromatin Loop Formation Mediated by RNA Polymerases Moving Cohesin Rings along DNA to CTCF-Binding Sites
Two RNA polymerases moving in opposite directions drive extrusion of chromatin loops through cohesin rings. The loop extrusion stops when cohesin encounters a DNA site occupied by CTCF on each side of a growing loop. Loop extrusion could be mediated either by a single cohesin ring or by two cohesin rings that embrace the chromatin fiber and are linked to each other either topologically or by complex formation (handcuff model).
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2017 Elsevier Inc. Terms and Conditions