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Fabry disease: An underrecognized cause of proteinuria

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Presentation on theme: "Fabry disease: An underrecognized cause of proteinuria"— Presentation transcript:

1 Fabry disease: An underrecognized cause of proteinuria
F.C. Fervenza, R. Torra, D.J. Lager  Kidney International  Volume 73, Issue 10, Pages (May 2008) DOI: /sj.ki Copyright © 2008 International Society of Nephrology Terms and Conditions

2 Figure 1 Proteinuria (g 24 h−1) before and after start of ERT.
Kidney International  , DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

3 Figure 2 Serum creatinine values before and after start of ERT.
Kidney International  , DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

4 Figure 3 Angiokeratomas: the red-purple maculopapular skin lesions characteristic of the disorder. (a) Skin lesions on buttocks, and (b) lesions on the umbilicus (provided by Dr Mark R Pittelkow, Department of Dermatology, Mayo Clinic, Rochester, MN). Kidney International  , DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

5 Figure 4 Glomerulus showing vacuolated podocytes (arrows) (hematoxylin and eosin, × 400). Kidney International  , DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

6 Figure 5 Glomerulus showing enlarged podocytes containing cytoplasmic lamellated inclusion bodies (arrows) (toluidine blue, × 600). Kidney International  , DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

7 Figure 6 Electron micrograph showing electron-dense laminated myelin figures in glomerular epithelial cells (× 5000). Kidney International  , DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions


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