1. Rescue of motor neurons from death The ventral root of the fifth lumbar segment (L5).
Rescue of motor neurons from death The ventral root of the fifth lumbar segment (L5). Saline: a saline‐injected AR2 mouse, AAV: a pre‐symptomatically AAV9‐Flag‐hADAR2 injected AR2 mouse (AAV), WT: a wild‐type mouse (39 weeks of age). Inset; magnified view. Scale bar: 20 and 64 µm for the insets.Numbers of axons in the ventral root in Saline (649.8 ± 17.8, n = 10; blue column), AAV (733.0 ± 28.6, n = 5; red column), and WT (840.0 ± 26.5, n = 3; white column) groups. All error bars represent the s.e.m. *p < 0.05 (Student's t‐test).Number of AHCs in L5 (n = 5 for each group). All error bars represent the s.e.m. **p < 0.01 (Student's t‐test). Numbers of AHCs in the unilateral AH are presented. Symbol colours are the same as in B.
Takenari Yamashita et al. EMBO Mol Med. 2013;5:
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