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Jin Wang, Li Xu, Erkang Wang  Biophysical Journal 

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1 Robustness and Coherence of a Three-Protein Circadian Oscillator: Landscape and Flux Perspectives 
Jin Wang, Li Xu, Erkang Wang  Biophysical Journal  Volume 97, Issue 11, Pages (December 2009) DOI: /j.bpj Copyright © 2009 Biophysical Society Terms and Conditions

2 Figure 1 The three-Kai oscillator when ATP is provided in excess.
Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2009 Biophysical Society Terms and Conditions

3 Figure 2 The integrated results for the three-dimensional system.
Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2009 Biophysical Society Terms and Conditions

4 Figure 3 The landscape and flux in the three dimensions T, D, and S of the circadian clock. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2009 Biophysical Society Terms and Conditions

5 Figure 4 (A) The barrier height Barrier1 =Ufix –Umin and Barrier2 =Ufix –Umax versus diffusion coefficient Dc. (B) The diffusion coefficient Dc versus the entropy production rate. (C) The barrier height Barrier1 =Ufix –Umin and Barrier2 =Ufix –Umax versus the entropy production rate. (D) The coherence versus the diffusion coefficient Dc and the entropy production rate. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2009 Biophysical Society Terms and Conditions

6 Figure 5 (A) The barrier height versus the scale. (B) The entropy production rate versus the scale. (C) The coherence versus the scale. (D) The standard deviation of period σPeriod and the mean of the period versus the scale. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2009 Biophysical Society Terms and Conditions

7 Figure 6 Scale = 2. (A) The barrier height versus Kd. (B) The entropy production rate versus Kd. (C) The coherence versus Kd. (D) The standard deviation of period σPeriod and the mean of the period versus Kd. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2009 Biophysical Society Terms and Conditions

8 Figure 7 The change of barrier height versus q for eight rate constants: 1, kSDA; 2, kUTA; 3, kTDA; 4, kUSA; 5, kTUA; 6, kDTA; 7:kDSA; and 8, kSUA. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2009 Biophysical Society Terms and Conditions

9 Figure 8 (A) The barrier height and entropy production rate versus q for kSDA. (B) The barrier height and entropy production rate versus q for kDTA. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2009 Biophysical Society Terms and Conditions

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