1. How to Determine The Chances of Disease
By ms. S. Brown

2. Warnings Is there a way to tell if someone is susceptible to disease?
How?
Is there a job specifically for this?

3. What is a Pedigree?
Has anyone heard of pedigrees in terms of horses or dogs?
Not just talking about dog food

4. Pedigree Pedigree is a chart of how traits are carried by a family
Symbols:
Boys:
Girls:
People who marry in are considered normal
Colors mean they have the trait (not necessarily dominat/recessive)
Potter Pedigree
Harry is a wizard. His father, James, was a wizard and his mother, Lily, was a witch. Both of Harry’s dad’s parents had magical abilities; however, Harry’s mother’s parents did not nor does her sister, Harry’s Aunt, Petunia. Petunia is married to Vernon Dursley and they have a son, Dudley. None of the Dursleys have magical powers. Use shading to indicate genotype. Also, write the names and genotypes below each of the circles or squares. For those who only one allele is known, write the known allele and a question mark. Complete the pedigree on the back of this paper. CP Biology
Usually pedigrees track disease What do you think of when you think disease? Disease has a negative connotation, but we can see that Magic is similar to a “disease” and it is just part of a factor of a person rather than the whole person. How can science terminology be used? In the case of pedigree, we are looking at how genes are passed from one biological parent to child according to X and Y chromosomes. These pedigrees are for specific contexts, as tracking disease. Thus, we look at the biological identity of a person; however, a person may not identify as their biological identity. Science terminology can be used to be objective and is looking at specific factors. Science terms are not supposed to be used to discriminate others. However, this has not always been the case. How has this not been the case? Why? This is due to who is in power in the science world. These pedigrees are for specific contexts, as tracking disease.

5. How to Draw a Pedigree My Family: Your Turn! 3 generations
Just learning how to trace a family (no trait yet)

6. Pedigree Now pick a trait and color it in through the pedigree
Eye Color in my Family:
Who do you think gave you this trait?
Is there a pattern?
Show eye color for my family (brown versus blue) -> talk about how there is a pattern (autosomal dominant) but it can be spontaneous
Autosomal dominant lead into Huntington Disease

7. Huntington’s Disease Neurodegenerative genetic disorder
What does that mean?
Affects muscle coordination and leads to mental decline
Symptoms appear between ages of years and worsen over a year period
Result of an addition mutation (CAG)
Approximately 30,000 symptomatic Americans
Fatal

8. Scenario 1: Huntington’s Disease
This is a family with Huntington’s Disease
What patterns do you notice?
Does it skip generations?
What is the ratio of affected children to not affected children in part II. I.
II.
III.

9. Scenario 1: Huntington’s Disease
Nevaeh and Jordan just got married and decided to have a baby together. However, Huntington’s Disease runs in both of their families. Jordan has Huntington’s Disease and is heterozygous. Nevaeh does not have Huntington’s disease and is homozygous. Draw the Punnett Square for original parents
What is the likelihood their child will have Huntington’s Disease?
Is Huntington’s Disease a dominant or recessive
trait? What pattern would you see on the pedigree?
What is dangerous about this inheritance pattern?

10. Scenario 1: Huntington’s Disease
What is the genotype of parents?
What is the genotypes of those
with Huntington’s Disease?
without Huntington’s Disease? I.
II.
III.

11. Autosomal Dominant-Tricks of the Trait
It does not skip generations
There are no carriers
Males and females have equal chance of being affected.
There is about a ½ chance a baby will get the trait if one of their parents have this trait
Normal siblings will not pass on the trait

12. Sickle Cell Disease Crescent blood cells Origin: Africa
Malaria Resistance
Affects about 90,000 to 100,000 Americans
1 in 500 Blacks or African-American Births
1 in 12 Blacks or African-Americans
Show another side of sickle cell after talking about how it was a point mutation in earlier classes

13. Scenario 2: Sickle Cell Anemia
This is a family with Sickle Cell Anemia
What patterns do you notice?
How is it different than Huntington’s Diseae I.
II.
III.
IV.

14. Scenario 2: Sickle Cell Anemia
MarÍa and Mateo are planning on having a child. They are each carriers for Sickle cell trait. What is a carrier?
Carrier: anybody carrying the trait but not expressing it
What are the chances their child will have sickle cell? Draw a Punnett Square
How many children will have sickle cell out of 4?

15. Scenario 2: Sickle Cell Anemia
What are the genotypes of parents
In number III?
What are these parents called?
What is the genotype of the affected
What are the possible genotypes of
The unaffected children? I.
II.
III.
IV.

16. Autosomal Recessive-Tricks of the Trait
Skips Generation
Males and Females are equally likely to be affected
On average, the recurrence risk to the unborn sibling of an affected individual is ¼
If only one parent is a carrier, children will not be affected
Usually no family history
Look at III 2-3 versus 7

17. End of Day 1

18. Sex-Linked Traits
What did we learn from this segment