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Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing  Akira Matsuda, MD, PhD, Yosuke Asada, MD, PhD, Naomasa Suita, MS,

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1 Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing 
Akira Matsuda, MD, PhD, Yosuke Asada, MD, PhD, Naomasa Suita, MS, Satoshi Iwamoto, MD, PhD, Toshiaki Hirakata, MD, Norihiko Yokoi, MD, PhD, Yasuyuki Ohkawa, PhD, Yukinori Okada, MD, PhD, Takehiko Yokomizo, MD, PhD, Nobuyuki Ebihara, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 143, Issue 4, Pages e6 (April 2019) DOI: /j.jaci Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig E1 Slitlamp photographs of AKC patient no. 1 (A and B), 2 (C and D), and 3 (E and F). Pannus (corneal neovascular) formation was observed in all cases (arrows). Formation of giant papillae was also observed in all 3 cases (Fig E1, B, D, and F). Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig E2 Volcano plots of DEGs (FDR < 0.05, fold change > 2, purple color) are shown. The fold change (diseases/control) of each transcript is plotted horizontally, and FDR in the form of −log10 (P value) of each transcript is plotted vertically. FDR, False discovery rate. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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