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The ribosome revealed Trends in Biochemical Sciences

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1 The ribosome revealed Trends in Biochemical Sciences
Peter B. Moore, Thomas A. Steitz  Trends in Biochemical Sciences  Volume 30, Issue 6, Pages (June 2005) DOI: /j.tibs Copyright © 2005 Elsevier Ltd Terms and Conditions

2 Figure 1 A space-filling model of the 70S ribosome generated using the structures of the Haloarcula marismortui large subunit [3] and the Thermus thermophilus small subunit [4] docked by superposition on the rRNA model for the T. thermophilus 70S ribosomes [20] in addition to the A-, P- and E-site tRNAs from that model. 23S rRNA and 5S rRNA are purple and white; the 16S rRNA is yellow. Ribosomal proteins of the large subunit are blue and those of the small subunit are green. The A-site tRNA with its 3′ end extending into the peptidyl-transferase cavity is red and the P-site tRNA is yellow. Reproduced, with permission, from Ref. [21]. Trends in Biochemical Sciences  , DOI: ( /j.tibs ) Copyright © 2005 Elsevier Ltd Terms and Conditions

3 Figure 2 Superposition of the structures of several antibiotics bound to the large ribosomal subunit from Haloarcula marismortui. The large subunit has been sliced open to reveal its peptidyl-transferase region, which is shown as a gray solvent contact surface, and an A-site substrate, CCA-puromycin (red), and a P-site substrate, CCA-phenylalanine-caproic acid-biotin (orange), are shown. The positions occupied by six antibiotics are displayed: sparsomycin (green), puromycin (red), blasticidin (purple), streptogramin A (cyan), carbomycin, which is a macrolide, (blue), and chloramphenicol (light blue). Reproduced, with permission, from Ref. [17]. Trends in Biochemical Sciences  , DOI: ( /j.tibs ) Copyright © 2005 Elsevier Ltd Terms and Conditions


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