1. Hemodynamic Thresholds for Precapillary Pulmonary Hypertension
Christian Gerges, MD, Mario Gerges, MD, Nika Skoro-Sajer, MD, Yi Zhou, PhD, Lixia Zhang, PhD, Roela Sadushi-Kolici, MD, Johannes Jakowitsch, PhD, Marie B. Lang, MD, Irene M. Lang, MD 
CHEST 
Volume 149, Issue 4, Pages (April 2016)
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2. Figure 1
Patient disposition. A, Retrospective cohort. A total of 1,410 patients were classified as having postcapillary PH, 257 as having precapillary PH, and 43 as having Multiple PH. Of these, 38 patients had iPAH. B, Treatment cohort. The cohort consisted of patients who were enrolled in four randomized placebo-controlled trials (gray shading; P01:03 [n = 26], P01:04 [n = 224], P01:05 [n = 246], and TRUST [n = 45]) and one open-label trial (P01:06 [n = 437]) of parenteral treprostinil in PAH. aOf those 283 patients, 238 received SC treprostinil; the remaining 45 patients (who were enrolled in TRUST) were treated with IV treprostinil. Cpc-PH = combined precapillary and postcapillary PH; CTEPH = chronic thromboembolic pulmonary hypertension; iPAH = idiopathic PAH; Ipc-PH = isolated postcapillary PH; PAH = pulmonary arterial hypertension; PH = pulmonary hypertension; RHC = right heart catherization; SC = subcutaneous; TRUST = Treprostinil IV for Untreated Symptomatic PAH Trial.
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3. Figure 2
Hemodynamic thresholds discriminating iPAH from isolated postcapillary PH. A, B, Receiver operating characteristic curves of mPAWP, CPA, mRAP, DPG, TPG, and PVR. A, Hemodynamic parameters that are higher in Ipc-PH. B, Hemodynamic parameters that are elevated in iPAH. Cutoffs were determined by maximizing the Youden index: mPAWP of 12 mm Hg, DPG of 7 mm Hg, TPG of 22 mm Hg, PVR of 4.5 WU, CPA of 1.3 mL/mm Hg, and mRAP of 7 mm Hg. AUC = area under the curve; CPA = pulmonary arterial compliance; DPG = diastolic pulmonary vascular pressure gradient; mPAWP = mean pulmonary arterial wedge pressure; mRAP = mean right atrial pressure; PVR = pulmonary vascular resistance; ROC = receiver operating characteristic; TPG = transpulmonary gradient; WU = Wood units. See Figure 1 legend for expansion of other abbreviations.
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4. Figure 3
Hemodynamic changes from baseline. Placebo-corrected changes from baseline in mRAP (A), PVR (B) and CPA (C). All values were normally distributed. P values are results of independent-sample t tests between placebo and treprostinil. See Figure 2 legend for expansion of abbreviations.
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5. Figure 4
Hemodynamic predictors of survival/freedom of lung transplantation. A-D, Multivariate flexible hazard ratio functions for mRAP and PVR at baseline (A, B) and follow-up (C, D). Analyses were adjusted for age, World Health Organization functional class, 6-min walk distance, and heart rate. Dashed blue lines mark CIs of the hazard functions. See Figure 2 legend for expansion of abbreviations.
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6. Figure 5
Hypothetical hemodynamic algorithm for the identification of PAH patients who are likely to experience a significant hemodynamic treatment response. Because of the retrospective nature of our study, prospective validation is needed. HFpEF = heart failure with preserved ejection fraction. See Figure 1 and 2 legends for expansion of other abbreviations.
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