1. CHAPTER 2 PRIMARY GLOMERULONEPHRITIS
Sunita Bavanandan Lim Soo Kun Lee Han Wei

2. Table 2.1: Primary Glomerulonephritis, 2005-2010
4th MRRB report 2010, Malaysia

3. Table 2.2.2(a): Demographic characteristics for MCD, 2005-2010n %
Age (year)
Mean (SD)
29.64 (12.86)
Median (IQR)
25.00 (16.87)
Min, max
15.00, 78.52
Gender
Male
438
65.6
Female
230
34.4
Race
Malay
405
60.6
Chinese
124
18.6
Indian 35
5.2
Others
104
15.6
4th MRRB report 2010, Malaysia

4. Figure 2.2.2(a): Demographic characteristics for MCD, 2005-2010
4th MRRB report 2010, Malaysia

5. Figure 2.2.2 (b): Age at time of biopsy (years) MCD, 2005-2010
Age group (years)
2005
2006
2007
2008
2009
2010
Total n %
15-<25 32
42.7 49
57.0 43
49.4 80
53.3 69
53.1 59
42.1
332
49.7
25-<35 20
26.7
23.3 17
19.5 35 28
21.5 30
21.4
150
22.5
35-<45 11
14.7 10
11.6 14
16.1 12
8.0 18
13.8 24
17.1 89
13.3
45-<55 4
4.7 6
6.9 8
6.2 21
15.0 61
9.1
55-<65 1
1.3 2
2.3 5
5.7 9
6.0 3
3.6 25
3.7
≥65
1.2
3.1
0.7
1.6 75
100 86 87
130
140
668
4th MRRB report 2010, Malaysia

6. Figure 2.2.2 (b): Age at time of biopsy (years) MCD, 2005-2010
4th MRRB report 2010, Malaysia

7. Table 2.2.3 (a): Clinical presentation for MCD, 2005-2010
Clinical Presentations
2005
2006
2007
2008
2009
2010
Total n %
Asymptomatic urine abnormality 3
4.0 9
10.5 12
13.8 19
12.7 16
12.3 20
14.3 79
11.8
Nephritic syndrome 2
2.7
3.5 4
4.6 5
3.3
3.1
2.9 22
Nephrotic syndrome 69
92.0 70
81.4 64
73.6
118
78.7 98
75.4
103
522
78.1
Nephritic-Nephrotic syndrome 1
1.3
2.3
3.4 6 7
5.4
6.4 28
4.2
Not available
0.0
3.8 17
2.5 75
100 86 87
150
130
140
668
4th MRRB report 2010, Malaysia

8. Figure 2.2.3 (a): Overall clinical presentation for MCD, 2005-201010 20 30 40 50 60 70 80 90
100
A. urine
abnormality
Nephritic
Nephrotic -
Not available
Percentage (%)
Clinical presentation
Clinical presentation 2005
2010
4th MRRB report 2010, Malaysia

9. Table 2.2.3 (b): Presence of hypertension in MCD, 2005-2010
2006
2007
2008
2009
2010
Total n %
Present 3
4.0 4
4.7 9
10.3 19
12.7 32
24.6 46
32.9
113
16.9
Absent 72
96.0 82
95.3 75
86.2
116
77.3 89
68.5 84
60.0
518
77.5
Missing
0.0
3.4 15
10.0
6.9 10
7.1 37
5.5
100 86 87
150
130
140
668
4th MRRB report 2010, Malaysia

10. Figure 2.2.3 (b): Presence of hypertension in MCD, 2005-20105 10 15 20 25 30 35
2005
2006
2007
2008
2009
2010
Percentage (%)
Year
Hypertension
4th MRRB report 2010, Malaysia

11. Table 2.2.3 (c): Renal function in MCD by year, 2005-2010
GFR
(ml/min/1.73 m2)
2005
2006
2007
2008
2009
2010
Total n %
<15
0.0 3
3.5 2
2.3
1.3 7
5.0 14
2.1
15 to < 30 1
1.2 5
5.7 4
2.7
5.4 25
3.7
30 to < 60 13
17.3 12
14.0 11
12.6 22
14.7 9
6.9 26
18.6 93
13.9
60 to < 90 19
25.3 17
19.8
28.7 27
18.0 28
21.5 18
12.9
134
20.1
> 90 36
48.0 48
55.8 42
48.3 86
57.3 77
59.2 67
47.9
356
53.3
Missing 6
8.0
5.8
6.0 15
10.7 46 75
100 87
150
130
140
668
*46 cases are missing on GFR, including 15 cases with GFR>200 (GFR range between 201 to 3349)
4th MRRB report 2010, Malaysia

12. Figure 2.2.3 (c): Impaired renal function in MCD by year, 2005-20105 10 15 20 25 30 35
2005
2006
2007
2008
2009
2010
Percentage (%)
Year
eGFR<60 ml/min
4th MRRB report 2010, Malaysia

13. 4th MRRB report 2010, Malaysia
Table (a): Clinical presentation by age group for MCD,
Clinical Presentations
15-<25
25-<35
35-<45
45-<55
55-<65
≥65
Total n %
Asymptomatic urine abnormality 32
9.6 20
13.3 12
13.5 8
13.1 4
16.0 3
27.3 79
11.8
Nephritic syndrome
3.6 6
4.0 2
2.2 1
1.6
0.0
9.1 22
3.3
Nephrotic syndrome
264
79.5
114
76.0 70
78.7 49
80.3 19
54.5
522
78.1
Nephritic-Nephrotic syndrome 18
5.4
2.7
3.4 28
4.2
Not available
1.8
8.0 17
2.5
332
100
150 89 61 25 11
668
4th MRRB report 2010, Malaysia

14. Table 2.2.3.1 (b): Hypertension by age group for MCD, 2005-2010
15-<25
25-<35
35-<45
45-<55
55-<65
≥65
Total n %
Present 45
13.6 18
12.0 21
23.6 20
32.8 8
32.0 1
9.1
113
16.9
Absent
272
81.9
121
80.7 63
70.8 37
60.7 17
68.0
72.7
518
77.5
Not available/ Missing 15
4.5 11
7.3 5
5.6 4
6.6
0.0 2
18.2
5.5
332
100
150 89 61 25
668
4th MRRB report 2010, Malaysia

15. Figure 2.2.3.1 (b): Hypertension by age group for MCD, 2005-20105 10 15 20 25 30 35 -
<25
<35
<45 45
<55 55
<65
≥65
Percentage (%)
Age group
Hypertension
4th MRRB report 2010, Malaysia

16. 4th MRRB report 2010, Malaysia
Table (c): Renal function at presentation by age group for MCD,
eGFR
(ml/min/1.73m2)
15- <25
25- <35
35- <45
45- <55
55- <65
≥65
Total n %
<15 6
1.8 2
1.3 3
3.4
0.0
8.0 1
9.1 14
2.1
15-29 8
9.0 4
6.6
16.0 25
3.7
30-59 31
9.3 16
10.7 13
14.6 23
37.7 5
20.0
45.5 93
13.9
60-89 55
16.6 28
18.7 27
30.3
23.0 7
28.0
27.3
134
20.1
≥90
207
62.3 92
61.3 32
36.0 18
29.5
24.0
356
53.3
Missing*
8.1 10
6.7
3.3
4.0 46
6.9
332
100
150 89 61 11
668
*Total of 46 cases are missing on GFR, including 15 cases with GFR>200 (GFR range between 201 to 3349)
4th MRRB report 2010, Malaysia

17. 4th MRRB report 2010, Malaysia
Figure (c): Impaired renal function at presentation by age group for MCD, 10 20 30 40 50 60 70 15 -
<25 25
<35 35
<45 45
<55 55
<65
≥65
Percentage (%)
Age group
eGFR<60ml/min
4th MRRB report 2010, Malaysia

18. Table 2.2.3.2 (a): Clinical presentation by gender for MCD, 2005-2010
Clinical Presentations
Male
Female n %
Asymptomatic urine abnormality 41
9.4 38
16.5
Nephritic syndrome 14
3.2 8
3.5
Nephrotic syndrome
344
78.5
178
77.4
Nephritic-Nephrotic syndrome 28
6.4
0.0
Not available 11
2.5 6
2.6
Total
438
100
230
4th MRRB report 2010, Malaysia

19. Table 2.2.3.2 (b): Hypertension by gender for MCD, 2005-2010
Male
Female n %
Present 72
16.4 41
17.8
Absent
340
77.6
178
77.4
Not available/ Missing 26
5.9 11
4.8
Total
438
100
230
4th MRRB report 2010, Malaysia

20. Figure 2.2.3.2 (b): Hypertension by gender for MCD, 2005-20102 4 6 8 10 12 14 16 18 20
Male
Female
Percentage (%)
Gender
Hypertension
4th MRRB report 2010, Malaysia

21. Table 2.2.3.2 (c): Renal function by gender for MCD, 2005-2010
eGFR
(ml/min/1.73m2)
Male
Female n %
<15 11
2.5 3
1.3
15-29 18
4.1 7
3.0
30-59 64
14.6 29
12.6
60-89 83
18.9 51
22.2
≥90
232
53.0
124
53.9
Missing* 30
6.8 16
7.0
Total
438
100
230
*Total of 46 cases are missing on GFR, including 15 cases with GFR>200 (GFR range between 201 to 3349)
4th MRRB report 2010, Malaysia

22. 4th MRRB report 2010, Malaysia
Figure (c): Impaired renal function by gender for MCD, 5 10 15 20 25 30
Male
Female
Percentage (%)
Gender
eGFR<60ml/min
4th MRRB report 2010, Malaysia

23. Table 2.3.2 (a): Demographic characteristics for FSGS, 2005-2010
n=598 %
Age
Mean (SD)
33.92 (14.36)
Median (IQR)
30.67 (20.48)
Min, max
15.00, 88.54
Gender
Male
341
57.0
Female
257
43.0
Race
Malay
378
63.2
Chinese
109
18.2
Indian 39
6.5
Others 72
12.0
4th MRRB report 2010, Malaysia

24. Figure 2.3.2(a): Demographic characteristics for FSGS, 2005-2010
Male,
57%
Female,
43%
Male,
57%
Female,
43%
Male,
57%
Female,
43%
Male,
57%
Female,
43%
Male,
57%
Female,
43%
Malay,
63%
Chinese,
18%
Indian, 7%
Others,
12%
4th MRRB report 2010, Malaysia

25. 4th MRRB report 2010, Malaysia
Table (b): Age group at time of biopsy (years) for FSGS,
Age group
(years)
2005
2006
2007
2008
2009
2010
Total n %
15-<25 19
31.1 46
43.4 30
34.5 35
34.3 36
31.0 39
205
25-<35 17
27.9 23
21.7 28
32.2 31
30.4 29
25.0
22.2
156
26.1
35-<45 13
21.3 18
17.0 15
17.2 14
13.7 24
20.7
23.8
114
19.1
45-<55 8
13.1 9
8.5
10.3
12.7 10
8.6
13.5 66
11.0
55-<65 3
4.9 5
4.7 4
4.6 6
5.9 7
5.6
≥65 1
1.6
1.1
2.9
6.0
4.0 22
3.7 61
100
106 87
102
116
126
598
4th MRRB report 2010, Malaysia

26. Figure 2.3.2 (b): Age at time of biopsy (years) for FSGS, 2005-2010
.01
.02
.03
.04
Density 20 40 60 80
100
Age at time of biopsy (years)
4th MRRB report 2010, Malaysia

27. Table 2.3.3 (a): Clinical presentation for FSGS, 2005-2010
Clinical Presentations
2005
2006
2007
2008
2009
2010
Total n %
Asymptomatic urine abnormality 10
16.4 19
17.9 17
19.5 29
28.4 35
30.2 33
26.2
143
23.9
Nephritic syndrome 4
6.6 5
4.7 6
6.9
5.9 3
2.6 7
5.6 31
5.2
Nephrotic syndrome 43
70.5 76
71.7 55
63.2 57
55.9 64
55.2 67
53.2
362
60.5
Nephritic-Nephrotic syndrome 1
1.6
0.0
3.9
8.6 12
9.5
5.5
Not available/ Missing
4.9
5.7
3.4
4.8 61
100
106 87
102
116
126
598
4th MRRB report 2010, Malaysia

28. Figure 2.3.3 (a): Overall clinical presentation for FSGS, 2005-201010 20 30 40 50 60 70 80
A. urine
abnormality
Nephritic
Nephrotic -
NA/ Missing
Percentage (%)
Clinical presentation
Clinical presentation 2005
2010
4th MRRB report 2010, Malaysia

29. Table 2.3.3 (b): Hypertension in FSGS, 2005-2010
2006
2007
2008
2009
2010
Total n %
Present 4
6.6
3.8 15
17.2 38
37.3 61
56.0 59
48.4
181
30.8
Absent 55
90.2
102
96.2 70
80.5 54
52.9 40
36.7 45
36.9
366
62.4
Not available/Missing 2
3.3
0.0
2.3 10
9.8 8
7.3 18
14.8
6.8
100
106 87
109
122
587
4th MRRB report 2010, Malaysia

30. Figure 2.3.3 (b): Hypertension in FSGS, 2005-201010 20 30 40 50 60
2005
2006
2007
2008
2009
2010
Percentage (%)
Year
Hypertension
4th MRRB report 2010, Malaysia

31. Table 2.3.3 (c): Renal function in FSGS by year, 2005-2010
GFR (ml/min/1.73m2)
2005
2006
2007
2008
2009
2010
Total n %
<15 3
4.9 2
1.9
2.3 7
6.9
6.0 10
7.9 31
5.2
15-29 8
13.1 14
13.2
9.2 9
8.8 22
19.0 17
13.5 78
13.0
30-59 19
31.1
16.0
25.3
30.4 30
25.9 24
143
23.9
60-89
11.5 27
25.5 25
28.7
16.7 26
22.4
126
21.1
≥90
36.1 40
37.7 32
31.4 42
33.3
183
30.6
Missing*
3.3 6
5.7 5
5.9
7.8
7.1 37
6.2 61
100
106 87
102
116
598
*Total of 37 cases are missing on GFR, including 9 cases with GFR>200 (GFR range between 205 to 511)
4th MRRB report 2010, Malaysia

32. Figure 2.3.3 (c): Impaired renal function in FSGS by year, 2005-201010 20 30 40 50 60
2005
2006
2007
2008
2009
2010
Percentage (%)
Year
eGFR<60ml/min
4th MRRB report 2010, Malaysia

33. 4th MRRB report 2010, Malaysia
Table (a): Clinical presentation by age group for FSGS,
Age group
(years)
15- <25
25-<35
35-<45
45-<55
55-<65
≥65
Total n %
Asymptomatic urine abnormality 29
14.1 55
35.3 32
28.1 16
24.2 8
22.9 3
14.3
143
23.9
Nephritic syndrome 11
5.4
7.1 5
4.4 1
1.5
8.6
0.0 31
5.2
Nephrotic syndrome
152
74.1 73
46.8 61
53.5 38
57.6 24
68.6 14
66.7
362
60.5
Nephritic-Nephrotic syndrome
3.9 9
5.8
7.0 6
9.1 2
9.5 33
5.5
Not available/ Missing
2.4
5.1
7.6
4.8
205
100
156
114 66 35 21
598
4th MRRB report 2010, Malaysia

34. Table 2.3.3.1 (b): Hypertension by age group for FSGS, 2005-2010
15- <25
25-<35
35-<45
45-<55
55-<65
≥65
Total n %
Present 39
19.0 41
26.3 43
37.7 31
47.0 16
45.7 11
50.0
181
30.3
Absent
148
72.2 99
63.5 63
55.3 15
42.9 10
45.5
366
61.2
Missing 18
8.8
10.3 8
7.0 4
6.1
11.4 1
4.5 51
8.5
205
100
156
114 66 35 22
598
4th MRRB report 2010, Malaysia

35. Figure 2.3.3.1 (b): Hypertension by age group for FSGS, 2005-201010 20 30 40 50 60 15 -
<25 25
<35 35
<45 45
<55 55
<65
≥65
Percentage (%)
Age group
Hypertension
4th MRRB report 2010, Malaysia

36. 4th MRRB report 2010, Malaysia
Table (c): Renal function at presentation by age group for FSGS,
GFR
(ml/min/1.73m2)
15- <25
25- <35
35- <45
45- <55
55- <65
≥65
Total n %
<15 8
3.9 6
3.8
5.3 5
7.6 3
8.6
13.6 31
5.2
15-29 11
5.4 20
12.8 19
16.7
22.9 9
40.9 78
13.0
30-59 43
21.0 36
23.1 28
24.6 22
33.3
25.7
22.7
143
23.9
60-89 32
15.6 34
21.8 30
26.3 16
24.2 10
28.6 4
18.2
126
21.1
≥90 93
45.4 52 27
23.7 7
10.6
11.4
0.0
183
30.6
Missing* 18
8.8
5.1
3.5 1
2.9
4.5 37
6.2
205
100
156
114 66 35
598
*Total of 37 cases are missing on GFR, including 9 cases with GFR>200 (GFR range between 205 to 511)
4th MRRB report 2010, Malaysia

37. 4th MRRB report 2010, Malaysia
Figure (c): Renal function at presentation by age group for FSGS, 10 20 30 40 50 60 70 80 90 15 -
<25 25
<35 35
<45 45
<55 55
<65
≥65
Percentage (%)
Age group
eGFR<60ml/min
4th MRRB report 2010, Malaysia

38. Table 2.3.3.2 (a): Clinical presentation by gender for FSGS, 2005-2010
Clinical Presentations
Male
Female
Total n %
Asymptomatic urine abnormality 62
18.2 81
31.5
143
23.9
Nephritic syndrome 17
5.0 14
5.4 31
5.2
Nephrotic syndrome
226
66.3
136
52.9
362
60.5
Nephritic-Nephrotic syndrome 21
6.2 12
4.7 33
5.5
Not available/ Missing 15
4.4 29
4.8
341
100
257
598
4th MRRB report 2010, Malaysia

39. Table 2.3.3.2 (b): Hypertension by gender in FSGS, 2005-2010
Male
Female
Total n %
Present
102
29.9 79
30.7
181
30.3
Absent
211
61.9
155
60.3
366
61.2
Missing 28
8.2 23
8.9 51
8.5
341
100
257
598
4th MRRB report 2010, Malaysia

40. Figure 2.3.3.2 (b): Hypertension by gender in FSGS, 2005-20105 10 15 20 25 30 35 40
Male
Female
Percentage (%)
Gender
Hypertension
4th MRRB report 2010, Malaysia

41. Table 2.3.3.2 (c): Renal function by gender for FSGS, 2005-2010
GFR
(ml/min/1.73m2)
Male
Female
Total n %
<15 14
4.1 17
6.6 31
5.2
15-29 44
12.9 34
13.2 78
13.0
30-59 80
23.5 63
24.5
143
23.9
60-89 73
21.4 53
20.6
126
21.1
≥90
109
32.0 74
28.8
183
30.6
Missing* 21
6.2 16 37
341
100
257
598
*Total of 37 cases are missing on GFR, including 9 cases with GFR>200 (GFR range between 205 to 511)
4th MRRB report 2010, Malaysia

42. 4th MRRB report 2010, Malaysia
Figure (c): Impaired renal function by gender in FSGS, 5 10 15 20 25 30 35 40 45 50
Male
Female
Percentage (%)
Gender
eGFR<60ml/min
4th MRRB report 2010, Malaysia

43. 4th MRRB report 2010, Malaysia
Table 2.4.2(a): Demographic characteristics of patients with IgA nephropathy,
Demographic Characteristics
n=421 %
Age (years)
Mean (SD)
33.16 (12.27)
Median (IQR)
31.44 (16.72)
Min, max
15.02, 85.25
Gender
Male
193
45.8
Female
228
54.2
Race
Malay
225
53.4
Chinese
117
27.8
Indian 32
7.6
Others 47
11.2
4th MRRB report 2010, Malaysia

44. 4th MRRB report 2010, Malaysia
Figure 2.4.2(a): Demographic characteristics of patients with IgA nephropathy,
Male,
46%
Female,
54%
Malay,
53%
Chinese,
28%
Indian, 8%
Others,
11%
4th MRRB report 2010, Malaysia

45. 4th MRRB report 2010, Malaysia
Table (b): Age group at time of biopsy (years) for IgA nephropathy,
Age group
(years)
2005
2006
2007
2008
2009
2010
Total n %
15-<25 5
16.1 15
29.4
28.3 29
31.9 35
38.9 31
29.5
130
30.9
25-<35 10
32.3 14
27.5 21
39.6 23
25.3
25.6 34
32.4
125
29.7
35-<45 11
21.6 8
15.1 22
24.4 19
18.1 93
22.1
45-<55 2
6.5
15.7 7
13.2
11.0
7.8 13
12.4 47
11.2
55-<65 3
9.7
3.9
3.8
3.3
2.2
6.7
4.5
≥65 1
3.2
2.0
0.0
1.1
1.0
1.7
100 51 53 91 90
105
421
4th MRRB report 2010, Malaysia

46. 4th MRRB report 2010, Malaysia
Figure (b): Age at time of biopsy (years) for IgA nephropathy,
.01
.02
.03
.04
Density 20 40 60 80
Age at time of biopsy (years)
4th MRRB report 2010, Malaysia

47. 4th MRRB report 2010, Malaysia
Table (a): Overall clinical presentation for IgA nephropathy,
Clinical Presentations
2005
2006
2007
2008
2009
2010
Total n %
Asymptomatic urine abnormality 19
61.3 20
39.2 28
52.8 58
63.7 39
43.3 51
48.6
215
51.1
Nephritic syndrome 1
3.2 3
5.9 4
7.5 8
8.8 6
6.7 10
9.5 32
7.6
Nephrotic syndrome
25.8 16
31.4 11
20.8 21
23.1 22
24.4 27
25.7
105
24.9
Nephritic-Nephrotic syndrome
0.0
3.3 12
13.3
Not available
9.7 9
17.6
11.3
1.1
12.2 7 37 31
100 53 91 90
421
4th MRRB report 2010, Malaysia

48. 4th MRRB report 2010, Malaysia
Figure (a): Overall clinical presentation for IgA nephropathy, 10 20 30 40 50 60 70
A. urine
abnormality
Nephritic
Nephrotic -
Not available
Percentage (%)
Clinical presentation
Clinical presentation 2005
2010
4th MRRB report 2010, Malaysia

49. Table 2.4.3 (b): Hypertension in IgA nephropathy, 2005-2010
2006
2007
2008
2009
2010
Total n %
Present 4
12.9 7
13.7 20
37.7 39
42.9 47
52.2 65
61.9
182
43.2
Absent 26
83.9 44
86.3 31
58.5 43
47.3 34
37.8 33
31.4
211
50.1
Not available/ Missing 1
3.2
0.0 2
3.8 9
9.9
10.0
6.7 28
100 51 53 91 90
105
421
4th MRRB report 2010, Malaysia

50. Table 2.4.3(c): Renal function in IgA nephropathy, 2005-2010
GFR (ml/min/1.73m2)
2005
2006
2007
2008
2009
2010
Total n % N
<15
0.0 6
11.8 7
13.2
7.7 11
12.2 25
23.8 56
13.3
15-29 4
12.9
13.7 5
9.4 8
8.8
6.7 12
11.4 42
10.0
30-59 9
29.0 15
29.4 13
24.5 24
26.4 22
24.4
21.0
105
24.9
60-89
41.9
15.1 19
20.9
21.1 16
15.2 90
21.4
≥90
16.1 18
34.0
27.5 26
28.9
22.9
104
24.7
Missing* 2
3.9
3.8
5.7 31
100 51 53 91
421
*Total of 24 cases are missing on GFR
4th MRRB report 2010, Malaysia

51. 4th MRRB report 2010, Malaysia
Table (a): Clinical presentation by age group for IgA nephropathy,
Age group
(years)
15- <25
25-<35
35-<45
45-<55
55-<65
≥65
Total n %
Asymptomatic urine abnormality 54
41.5 68
54.4 53
57.0 23
48.9 15
78.9 2
28.6
215
51.1
Nephritic syndrome 17
13.1 12
9.6
2.2 1
2.1
0.0 32
7.6
Nephrotic syndrome 39
30.0
18.4 21
22.6
36.2
10.5 3
42.9
105
24.9
Nephritic-Nephrotic syndrome
9.2 9
7.2 8
8.6
4.3
5.3
Missing
6.2 13
10.4
9.7 4
8.5 37
8.8
130
100
125 93 47 19 7
421
4th MRRB report 2010, Malaysia

52. 4th MRRB report 2010, Malaysia
Table (b): Hypertension by age group for IgA nephropathy,
Hypertension
15- <25
25-<35
35-<45
45-<55
55-<65
≥65
Total n %
Present 51
39.2 47
37.6 45
48.4 26
55.3 8
42.1 5
71.4
182
43.2
Absent 71
54.6 64
51.2 44
47.3 20
42.6 10
52.6 2
28.6
211
50.1
Missing
6.2 14
11.2 4
4.3 1
2.1
5.3
0.0 28
6.7
130
100
125 93 19 7
421
4th MRRB report 2010, Malaysia

53. 4th MRRB report 2010, Malaysia
Figure (b): Hypertension by age group for IgA nephropathy, 10 20 30 40 50 60 70 80 15 -
<25 25
<35 35
<45 45
<55 55
<65
≥65
Percentage (%)
Age group
Hypertension
4th MRRB report 2010, Malaysia

54. 4th MRRB report 2010, Malaysia
Table (c): Renal function at presentation by age group for IgA nephropathy,
GFR
(ml/min/1.73m2)
15- <25
25- <35
35- <45
45- <55
55- <65
≥65
Total n %
<15 12
9.2 14
11.2 13
14.0
25.5 4
21.1 1
14.3 56
13.3
15-29
10.0
10.4 6
6.5
8.5 3
15.8
42.9 42
30-59 28
21.5 34
27.2 25
26.9
29.8 2
10.5
28.6
105
24.9
60-89 17
13.1 30
24.0
31.6
0.0 90
21.4
≥90 50
38.5
18.3
104
24.7
Missing* 10
7.7
3.2 7
7.5
2.1 24
5.7
130
100
125 93 47 19
421
*Total of 24 cases are missing on GFR
4th MRRB report 2010, Malaysia

55. 4th MRRB report 2010, Malaysia
Figure (c): Impaired renal function at presentation by age group for IgA nephropathy, 10 20 30 40 50 60 70 80 90
100 15 -
<25 25
<35 35
<45 45
<55 55
<65
≥65
Percentage (%)
Age group
eGFR<60ml/min
4th MRRB report 2010, Malaysia

56. 4th MRRB report 2010, Malaysia
Table (a): Clinical presentation by gender for IgA nephropathy,
Clinical Presentations
Male
Female
Total n %
Asymptomatic urine abnormality 91
47.2
124
54.4
215
51.1
Nephritic syndrome 16
8.3
7.0 32
7.6
Nephrotic syndrome 53
27.5 52
22.8
105
24.9
Nephritic-Nephrotic syndrome 15
7.8 17
7.5
Not available 18
9.3 19 37
8.8
193
100
228
421
4th MRRB report 2010, Malaysia

57. 4th MRRB report 2010, Malaysia
Table (b): Hypertension by gender for IgA nephropathy,
Hypertension
Male
Female
Total n %
Present 91
47.2
39.9
182
43.2
Absent 92
47.7
119
52.2
211
50.1
Missing 10
5.2 18
7.9 28
6.7
193
100
228
421
4th MRRB report 2010, Malaysia

58. 4th MRRB report 2010, Malaysia
Figure (b): Hypertension by gender for IgA nephropathy, 10 20 30 40 50 60
Male
Female
Percentage (%)
Gender
Hypertension
4th MRRB report 2010, Malaysia

59. 4th MRRB report 2010, Malaysia
Table (c): Renal function by gender for IgA nephropathy,
GFR
(ml/min/1.73m2)
Male
Female
Total n %
<15 25
13.0 31
13.6 56
13.3
15-29 27
14.0 15
6.6 42
10.0
30-59 47
24.4 58
25.4
105
24.9
60-89 33
17.1 57
25.0 90
21.4
≥90 49 55
24.1
104
24.7
Missing* 12
6.2
5.3 24
5.7
193
100
228
421
*Total of 24 cases are missing on GFR
4th MRRB report 2010, Malaysia

60. Figure 2.4.3.2 (c): Impaired renal function by gender in 2005-201010 20 30 40 50 60
Male
Female
Percentage (%)
Gender
eGFR<60ml/min
4th MRRB report 2010, Malaysia

61. Table 2.5.2 (a): Demographic characteristics for IMN, 2005-2010%
Age (years)
Mean (SD)
44.81 (15.17)
Median (IQR)
44.07 (22.55)
Min, max
15.11, 84.35
Gender
Male
100
53.2
Female 88
46.8
Race
Malay 79
42.0
Chinese 70
37.2
Indian 16
8.5
Other 23
12.2
4th MRRB report 2010, Malaysia

62. Figure 2.5.2 (a): Demographic characteristics for IMN, 2005-2010
Malay,
42%
Chinese,
37%
Indian, 9%
Other,
12%
Male,
53%
Female,
47%
4th MRRB report 2010, Malaysia

63. 4th MRRB report 2010, Malaysia
Table (b): Age group at time of biopsy (years) for IMN,
Age group (years)
2005
2006
2007
2008
2009
2010
Total n %
15-<25 3
13.0 1
3.0 2
6.1 5
13.5 4
16.0 20
10.6
25-<35
17.4 8
24.2
21.6
12.0 36
19.1
35-<45
15.2 6
18.2 12
32.4 39
20.7
45-<55 7
21.2 10
30.3 9
36.0 45
23.9
55-<65
9.1
16.2
8.0
8.1 28
14.9
≥ 65
21.7
12.1
5.4
10.8 23
100 33 37 25
188
4th MRRB report 2010, Malaysia

64. Figure 2.5.2 (b): Age at time of biopsy (years) for IMN, 2005-2010
.01
.02
.03
Density 20 40 60 80
Age at time of biopsy (years)
4th MRRB report 2010, Malaysia

65. Table 2.5.3 (a): Overall clinical presentation for IMN, 2005-2010
Clinical Presentations
2005
2006
2007
2008
2009
2010
Total n %
Asymptomatic urine abnormality 1
4.3 8
24.2 9
27.3 10
27.0 11
44.0 6
16.2 45
23.9
Nephritic syndrome
3.0
0.0
2.7 3
1.6
Nephrotic syndrome 20
87.0 21
63.6 23
69.7
62.2 13
52.0 29
78.4
129
68.6
Nephritic-Nephrotic syndrome 2
5.4
4.0
3.2
Not available
6.1 5
100 33 37 25
188
4th MRRB report 2010, Malaysia

66. Figure 2.5.3 (a): Clinical presentation for IMN, 2005-201010 20 30 40 50 60 70 80
A. urine
abnormality
Nephritic
Nephrotic -
Not available
Percentage (%)
Clinical presentation
Clinical presentation 2005
2010
4th MRRB report 2010, Malaysia

67. Table 2.5.3 (b): Hypertension in IMN, 2005-2010
2006
2007
2008
2009
2010
Total n %
Present 6
26.1 3
9.1 2
6.1 15
40.5 8
32.0 14
37.8 48
25.5
Absent 17
73.9 30
90.9 19
51.4
60.0
45.9
128
68.1
Not available
0.0 1
3.0
8.1
8.0
16.2 12
6.4 23
100 33 37 25
188
4th MRRB report 2010, Malaysia

68. Table 2.5.3(c): Renal function in IMN, 2005-2010
GFR (ml/min/1.73m2)
2005
2006
2007
2008
2009
2010
Total n %
<15
0.0 1
3.0 2
6.1
4.0 4
2.1
15-29 3
13.0
9.1
5.4
8.1 13
6.9
30-59
17.4 12
36.4 8
24.2 9
24.3
12.0 6
16.2 42
22.3
60-89
26.1 14
37.8 11
44.0 7
18.9 54
28.7
≥90 10
43.5
30.3
27.0
32.0 19
51.4 65
34.6
Missing*
8.0
5.3 23
100 33 37 25
188
*Total of 10 cases are missing on GFR, including 4 cases with GFR>200 (GFR range between 207 to 1312)
4th MRRB report 2010, Malaysia

69. Figure 2.5.3(c): Renal function in IMN, 2005-201010 20 30 40 50 60
2005
2006
2007
2008
2009
2010
Percentage (%)
Year
eGFR<60ml/min
4th MRRB report 2010, Malaysia

70. 4th MRRB report 2010, Malaysia
Table (a): Clinical presentation by age group for IMN,
Age group (years)
15- <25
25-<35
35-<45
45-<55
55-<65
≥65
Total n %
Asymptomatic urine abnormality 5
25.0 8
22.2
20.5 11
24.4 12
42.9 1
5.0 45
23.9
Nephritic syndrome
0.0 2
4.4
3.6 3
1.6
Nephrotic syndrome
60.0 26
72.2 28
71.8 30
66.7 14
50.0 19
95.0
129
68.6
Nephritic-Nephrotic syndrome
10.0
5.1 6
3.2
Not available
5.6
2.6
2.7 20
100 36 39
188
4th MRRB report 2010, Malaysia

71. Table 2.5.3.1(b): Hypertension by age group for IMN, 2005-2010
15- <25
25-<35
35-<45
45-<55
55-<65
>=65
Total n %
Present 7
35.0 4
11.1 10
25.6 8
17.8 11
39.3
40.0 48
25.5
Absent 12
60.0 29
80.6 26
66.7 34
75.6 15
53.6
128
68.1
Not available 1
5.0 3
8.3
7.7
6.7 2
7.1
0.0
6.4 20
100 36 39 45 28
188
4th MRRB report 2010, Malaysia

72. Figure 2.5.3.1 (b): Hypertension by age group for IMN, 2005-20105 10 15 20 25 30 35 40 45 -
<25
<35
<45
<55 55
<65
≥65
Percentage (%)
Age group
Hypertension
4th MRRB report 2010, Malaysia

73. 4th MRRB report 2010, Malaysia
Table (c): Renal function at presentation by age group for IMN,
eGFR
(ml/min/1.73m2)
15- <25
25- <35
35- <45
45- <55
55- <65
≥ 65
Total n %
<15
0.0 1
2.8
2.6
2.2
3.6 4
2.1
15-29
5.0 2
5.6 3
6.7
10.7
15.0 13
6.9
30-59 5
13.9 6
15.4 9
20.0
32.1 12
60.0 42
22.3
60-89
25.0
30.8 19
42.2 10
35.7 54
28.7
≥90 17
85.0
47.2
43.6 11
24.4
7.1 65
34.6
Missing*
5.1
4.4
5.3 20
100 36 39 45 28
188
*Total of 10 cases are missing on GFR, including 4 cases with GFR>200 (GFR range between 207 to 1312)
4th MRRB report 2010, Malaysia

74. 4th MRRB report 2010, Malaysia
Figure (c): Renal function at presentation by age group for IMN, 10 20 30 40 50 60 70 80 15 -
<25 25
<35 35
<45 45
<55 55
<65
≥65
Percentage (%)
Age group
eGFR<60ml/min
4th MRRB report 2010, Malaysia

75. Table 2.5.3.2 (a): Clinical presentation by gender for IMN, 2005-2010
Clinical Presentations
Male
Female
Total n %
Asymptomatic urine abnormality 24
24.0 21
23.9 45
Nephritic syndrome 2
2.0 1
1.1 3
1.6
Nephrotic syndrome 68
68.0 61
69.3
129
68.6
Nephritic-Nephrotic syndrome
3.0
3.4 6
3.2
Not available
2.3 5
2.7
100 88
188
4th MRRB report 2010, Malaysia

76. Table 2.5.3.2 (b): Hypertension by gender for IMN, 2005-2010
Male
Female
Total n %
Present 27
27.0 21
23.9 48
25.5
Absent 68
68.0 60
68.2
128
68.1
Missing 5
5.0 7
8.0 12
6.4
100 88
188
4th MRRB report 2010, Malaysia

77. Figure 2.5.3.2 (b): Hypertension by gender for IMN, 2005-20105 10 15 20 25 30 35
Male
Female
Percentage (%)
Gender
Hypertension
4th MRRB report 2010, Malaysia

78. Table 2.5.3.2 (c): Renal function by gender for IMN, 2005-2010
GFR
(ml/min/1.73m2)
Male
Female
Total n %
<15 2
2.0
2.3 4
2.1
15-29 9
9.0
4.5 13
6.9
30-59 26
26.0 16
18.2 42
22.3
60-89 34
34.0 20
22.7 54
28.7
≥90 25
25.0 40
45.5 65
34.6
Missing*
4.0 6
6.8 10
5.3
100 88
188
*Total of 10 cases are missing on GFR, including 4 cases with GFR>200 (GFR range between 207 to 1312)
4th MRRB report 2010, Malaysia

79. 4th MRRB report 2010, Malaysia
Figure (c): Impaired renal function by gender for IMN, 5 10 15 20 25 30 35 40 45
Male
Female
Percentage (%)
Gender
eGFR<60ml/min
4th MRRB report 2010, Malaysia