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Martin Heine, Anna Karpova, Eckart D. Gundelfinger  Neuron 

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Presentation on theme: "Martin Heine, Anna Karpova, Eckart D. Gundelfinger  Neuron "— Presentation transcript:

1 Counting Gephyrins, One at a Time: A Nanoscale View on the Inhibitory Postsynapse 
Martin Heine, Anna Karpova, Eckart D. Gundelfinger  Neuron  Volume 79, Issue 2, Pages (July 2013) DOI: /j.neuron Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Hypothetical Organization of Gephyrin Clusters and Associated Neurotransmitter Receptors in an Inhibitory Spinal Cord Postsynapse (A) Gephyrin can bind to cytoplasmic loops of some, but not all, subunits of pentameric inhibitory receptors. Both GlyRs and GABAARs can be recruited into gephyrin clusters. There is one binding site per gephyrin E-domain. Accordingly one can assume that one receptor with two binding subunits can be accommodated per gephyrin dimer. G, gephyrin G-domain; E, gephyrin E-domain. (B) Gephyrins are supposed to form a hexoganal lattice assembled from dimers of trimers of the molecule. Work by Specht et al., (2013) indicates that the packaging density is higher for GlyR subdomains (light blue area) than for subdomains occupied by GABAARs. Theoretically this could be achieved by a smaller mesh size of the lattice (indicated by the iris with question mark) or by gaps within the assembly of the lattice (light green area). Neuron  , DOI: ( /j.neuron ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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