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Long-term survival of cardiac xenografts in fully xenogeneic (mouse → rat) bone marrow chimeras  Muhammad M Mohiuddin, MD, Yong Qin, MD, Xiaohua Qian,

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Presentation on theme: "Long-term survival of cardiac xenografts in fully xenogeneic (mouse → rat) bone marrow chimeras  Muhammad M Mohiuddin, MD, Yong Qin, MD, Xiaohua Qian,"— Presentation transcript:

1 Long-term survival of cardiac xenografts in fully xenogeneic (mouse → rat) bone marrow chimeras 
Muhammad M Mohiuddin, MD, Yong Qin, MD, Xiaohua Qian, MD, PhD, Yuru Meng, MD, Verdi J DiSesa, MD  The Annals of Thoracic Surgery  Volume 72, Issue 3, Pages (September 2001) DOI: /S (01)

2 Fig 1 Flow cytometric analysis of peripheral blood lymphocytes of one representative chimeric rat 30 days after reconstitution with donor marrow showing complete replacement with mouse donor cells: peripheral blood lymphocytes were stained by (A) FITC labeled antirat MHC Class I antibody (RT1AAVL) and (B) PE labeled mouse anti-Class I antibody (H2Kk). Unfilled histogram contains unstained cells and the filled histogram stained cells. The Annals of Thoracic Surgery  , DOI: ( /S (01) )

3 Fig 2 Percentage survival of cardiac grafts (Kaplan-Meier method).
The Annals of Thoracic Surgery  , DOI: ( /S (01) )

4 Fig 3 Proliferative response of lymphocytes from chimeric rats to irradiated stimulators. The Annals of Thoracic Surgery  , DOI: ( /S (01) )

5 Fig 4 Measurement of IgG and IgM antibody titers in the naı̈ve, chimeric, and sensitized animals. The Annals of Thoracic Surgery  , DOI: ( /S (01) )

6 Fig 5 Antibody-mediated cytotoxicity.
The Annals of Thoracic Surgery  , DOI: ( /S (01) )

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