1. Volume 116, Issue 5, Pages 1167-1175 (May 1999)
Selective inhibition of cyclooxygenase 2 spares renal function and prostaglandin synthesis in cirrhotic rats with ascites 
Marta Bosch–Marcé*, Joan Clària*, Esther Titos*, Jaime L. Masferrer‡, Rosario Altuna§, Jorge–Luís Poo∥, Wladimiro Jiménez¶, Vicente Arroyo∥, Francisca Rivera¶, Joan Rodés∥ 
Gastroenterology 
Volume 116, Issue 5, Pages (May 1999)
DOI: /S (99)70020-X
Copyright © 1999 American Gastroenterological Association Terms and Conditions

2. Fig. 1
UPGE2V and U6-keto-PGF1αV in cirrhotic rats with ascites under baseline conditions (□) and 60 minutes after administration of COX inhibitors (▨; ketorolac, n = 8; SC-236, n = 9). Values represent means ± SEM. Data are compared by the Studentt test for paired data.
Gastroenterology  , DOI: ( /S (99)70020-X)
Copyright © 1999 American Gastroenterological Association Terms and Conditions

3. Fig. 2
Percent changes in V, UNaV, GFR, RPF, and UPGE2V induced by SC-236 (□; n = 12) or ketorolac (▨; n = 10) in cirrhotic rats with ascites. Values represent means ± SEM and correspond to the changes observed 60 minutes after the administration of COX inhibitors. Data are compared by the Student t test for unpaired data.
Gastroenterology  , DOI: ( /S (99)70020-X)
Copyright © 1999 American Gastroenterological Association Terms and Conditions

4. Fig. 3
Ex vivo TXB2 production under baseline conditions (□) and after administration of COX inhibitors (▨) to rats with cirrhosis and ascites (ketorolac, n = 5; SC-236, n = 5). Whole blood samples were exposed to ionophore A23187 (10 minutes, 37°C), and the incubations were terminated by addition of cold methanol. TXB2 levels were determined in unextracted samples by ELISA. Results are given as means ± SEM. Data are compared by the Student t test for paired data.
Gastroenterology  , DOI: ( /S (99)70020-X)
Copyright © 1999 American Gastroenterological Association Terms and Conditions

5. Fig. 4
COX-1 and COX-2 mRNA expression in renal tissue isolated from control and cirrhotic rats with ascites. Total RNA was subjected to RT-PCR using specific oligonucleotides for COX-1, COX-2, and GAPDH. RNA isolated from Raw macrophages was used as a positive control (first lane at right). These agarose gels are representative of results obtained from 3 different experiments.
Gastroenterology  , DOI: ( /S (99)70020-X)
Copyright © 1999 American Gastroenterological Association Terms and Conditions

6. Fig. 5
Effects of ketorolac (n = 15) and SC-236 (n = 13) on renal water metabolism in rats with cirrhosis and ascites in protocol 2. (A) Percent water load excreted and (B) mUOsm were measured under baseline conditions (□) and after administration of COX inhibitors (▨) to cirrhotic rats. Results represent means ± SEM. Data are compared by the Student t test for paired data.
Gastroenterology  , DOI: ( /S (99)70020-X)
Copyright © 1999 American Gastroenterological Association Terms and Conditions