1. Statistical simulation using data from the foundation for the national institute of health/osteoarthritis initiative biomarkers consortium to evaluate the clinical utility of prognostic knee osteoarthritis biomarkers in designing a knee osteoarthritis clinical trial 
S. Feng, Z. Liu, F. Hong, J. Medema, R. Kamath, M. Levesque 
Osteoarthritis and Cartilage 
Volume 25, Pages S34-S35 (April 2017)
DOI: /j.joca
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2. Fig. 1
Potential benefit* and eost† of using urine CTX-II, MRI/BML, or no biomarker (reference) in a future knee OΛ trial. BML, bone marrow lesion; CTX-II, C-telopeptide of type 2 collagen; MRI, magnetic resonance imaging; OA, osteoarthritis. *Enrichment of progressers. †Size of subgroup or screen failure rate.
Osteoarthritis and Cartilage  , S34-S35DOI: ( /j.joca )
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