1. Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches 
David Gallardo, Anna Bosch-Vizcaya, Rocío Rodríguez-Romanos, Nazly Santos, Ismael Buño, Rafael de la Cámara, Salut Brunet, Antonio Jiménez-Velasco, Marcos González, Jose B. Nieto, Carolina Martínez-Laperche, Carlos Vallejo, Christelle Ferrá, Antònia Sampol, Javier López-Jiménez, Jose A. Pérez-Simón, Carmen Martínez, Jose L. Díez 
Biology of Blood and Marrow Transplantation 
Volume 23, Issue 12, Pages (December 2017)
DOI: /j.bbmt
Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

2. Figure 1
Cumulative incidence of grade II, III, or IV acute GVHD. The probability of grade II, III, or IV acute GVHD is shown for patients with a specific minor histocompatibility mismatch (solid line) or without this mismatch (dashed line). (A) Cumulative incidence of acute GVHD grades II, III, or IV associated with the presence of the HA-1 mismatch when transplanted from a donor with CTLA-4 rs AA genotype. (B) Effect of the same mismatch when the donor presented the CTLA-4 rs AG or GG genotype. The same comparison is performed analyzing the impact of the H-Y mismatch on grade II, III, or IV acute GVHD associated with the presence of the H-Y mismatch when the donor has the CTLA-4 rs AA genotype (C) versus the CTLA-4 rs AG or GG genotype (D). Both mismatches were associated with a higher incidence of grade II, III, or IV acute GVHD only when the donor had the CTLA-4 rs AA genotype. P values were estimated from multivariable regression models adjusted for source of stem cells, diagnosis, and GVHD prophylaxis.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt )
Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

3. Figure 2
Cumulative incidence of grade III or IV acute GVHD. The probability of grade III or IV acute GVHD is shown for patients with a specific minor histocompatibility mismatch (solid line) or without this mismatch (dashed line). (A) Cumulative incidence of acute GVHD grades III or IV associated with the presence of the HA-8 mismatch when transplanted from a donor with CTLA-4 rs AA genotype. (B) Effect of the same mismatch when the donor presented the CTLA-4 rs AG or GG genotype. The same comparison is performed analyzing the impact of the H-Y mismatch on grade III or IV acute GVHD associated with the presence of the H-Y mismatch when donor has the CTLA-4 rs AA genotype (C) versus the CTLA-4 rs AG or GG genotype (D). Both mismatches were associated with a higher incidence of grade III or IV acute GVHD only when the donor had the CTLA-4 rs AA genotype. P values were estimated from multivariable regression models adjusted for source of stem cells, diagnosis and GVHD prophylaxis.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt )
Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions