Download presentation
Presentation is loading. Please wait.
1
Volume 23, Issue 12, Pages 1458-1467 (December 2016)
MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates Stephanie M. Reeve, Eric W. Scocchera, Narendran G-Dayanadan, Santosh Keshipeddy, Jolanta Krucinska, Behnoush Hajian, Jacob Ferreira, Michael Nailor, Jeffrey Aeschlimann, Dennis L. Wright, Amy C. Anderson Cell Chemical Biology Volume 23, Issue 12, Pages (December 2016) DOI: /j.chembiol Copyright © 2016 Elsevier Ltd Terms and Conditions
2
Cell Chemical Biology 2016 23, 1458-1467DOI: (10. 1016/j. chembiol
Copyright © 2016 Elsevier Ltd Terms and Conditions
3
Figure 1 Clonal Characterization of S. aureus Strains by spaA Sequencing Cell Chemical Biology , DOI: ( /j.chembiol ) Copyright © 2016 Elsevier Ltd Terms and Conditions
4
Figure 2 Structure of PLAs in This Study
Cell Chemical Biology , DOI: ( /j.chembiol ) Copyright © 2016 Elsevier Ltd Terms and Conditions
5
Figure 3 Crystal Structure of SaDHFR Bound to NADPH, Orange, and UCP1191, Cyan An overview of the ligand in the active site (A); a more detailed view of the interaction with Arg 57 (B). The hydrogen bonding interactions between the protein and inhibitor are shown in black (PDB: 5JG0). Cell Chemical Biology , DOI: ( /j.chembiol ) Copyright © 2016 Elsevier Ltd Terms and Conditions
6
Figure 4 Sequence Alignment of Proteins Resulting from Chromosomal DHFR, dfrB, and Plasmid-Acquired DHFR Genes, dfrG, dfrK, and dfrA Cell Chemical Biology , DOI: ( /j.chembiol ) Copyright © 2016 Elsevier Ltd Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.