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Volume 23, Issue 12, Pages (December 2016)

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Presentation on theme: "Volume 23, Issue 12, Pages (December 2016)"— Presentation transcript:

1 Volume 23, Issue 12, Pages 1458-1467 (December 2016)
MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates  Stephanie M. Reeve, Eric W. Scocchera, Narendran G-Dayanadan, Santosh Keshipeddy, Jolanta Krucinska, Behnoush Hajian, Jacob Ferreira, Michael Nailor, Jeffrey Aeschlimann, Dennis L. Wright, Amy C. Anderson  Cell Chemical Biology  Volume 23, Issue 12, Pages (December 2016) DOI: /j.chembiol Copyright © 2016 Elsevier Ltd Terms and Conditions

2 Cell Chemical Biology 2016 23, 1458-1467DOI: (10. 1016/j. chembiol
Copyright © 2016 Elsevier Ltd Terms and Conditions

3 Figure 1 Clonal Characterization of S. aureus Strains by spaA Sequencing Cell Chemical Biology  , DOI: ( /j.chembiol ) Copyright © 2016 Elsevier Ltd Terms and Conditions

4 Figure 2 Structure of PLAs in This Study
Cell Chemical Biology  , DOI: ( /j.chembiol ) Copyright © 2016 Elsevier Ltd Terms and Conditions

5 Figure 3 Crystal Structure of SaDHFR Bound to NADPH, Orange, and UCP1191, Cyan An overview of the ligand in the active site (A); a more detailed view of the interaction with Arg 57 (B). The hydrogen bonding interactions between the protein and inhibitor are shown in black (PDB: 5JG0). Cell Chemical Biology  , DOI: ( /j.chembiol ) Copyright © 2016 Elsevier Ltd Terms and Conditions

6 Figure 4 Sequence Alignment of Proteins Resulting from Chromosomal DHFR, dfrB, and Plasmid-Acquired DHFR Genes, dfrG, dfrK, and dfrA Cell Chemical Biology  , DOI: ( /j.chembiol ) Copyright © 2016 Elsevier Ltd Terms and Conditions


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