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Matrix metalloproteinase 10 is associated with disease severity and mortality in patients with peripheral arterial disease  Esther Martinez-Aguilar, MD,

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Presentation on theme: "Matrix metalloproteinase 10 is associated with disease severity and mortality in patients with peripheral arterial disease  Esther Martinez-Aguilar, MD,"— Presentation transcript:

1 Matrix metalloproteinase 10 is associated with disease severity and mortality in patients with peripheral arterial disease  Esther Martinez-Aguilar, MD, Violeta Gomez-Rodriguez, BS, Josune Orbe, PhD, Jose A. Rodriguez, PhD, Leopoldo Fernández-Alonso, MD, PhD, Carmen Roncal, PhD, Jose A. Páramo, MD, PhD  Journal of Vascular Surgery  Volume 61, Issue 2, Pages (February 2015) DOI: /j.jvs Copyright © 2015 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Circulating levels of matrix metalloproteinase 10 (MMP-10) are increased in patients with peripheral arterial disease (PAD) according to the disease severity. A, MMP-10 levels were measured in control subjects (Ctrl, n = 200) and PAD patients (n = 187). PAD patients were then divided according to disease severity into intermittent claudication (IC, n = 99) and critical limb ischemia (CLI, n = 88). B, Tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) was decreased in PAD patients. C, MMP-10/TIMP-1 ratio was increased in patients compared with controls. D, Receiver operating characteristic (ROC) curve for MMP-10 plotted for various cutoff values to determine PAD. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Matrix metalloproteinase 10 (MMP-10) is associated with clinical outcome in peripheral arterial disease (PAD). A, Circulating MMP-10 levels are increased in PAD patients who died. B and C, Kaplan-Meier estimates for cumulative death (B) and amputation (C) in PAD patients in relation to MMP-10 tertiles (C, log-rank test, P < .05). D, Kaplan-Meier estimates for cumulative cardiovascular (CV) mortality (log-rank test, P < .05). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Morphologic analysis showing matrix metalloproteinase 10 (MMP-10) expression in atherosclerotic femoral arteries. A, Hematoxylin-eosin (HE) staining of femoral artery section. B, Higher magnification detail of HE-stained sections. C and D, Immunohistochemistry for CD68 macrophage marker and a higher magnification detail (D). E and F, Immunohistochemistry for MMP-10 and a higher magnification detail (F). Scale bar in A, C, and E denotes 250 μm. Scale bar in B, D, and F denotes 10 μm. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

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