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John E. Levine, Sophie Paczesny, Stefanie Sarantopoulos 

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Presentation on theme: "John E. Levine, Sophie Paczesny, Stefanie Sarantopoulos "— Presentation transcript:

1 Clinical Applications for Biomarkers of Acute and Chronic Graft-versus-Host Disease 
John E. Levine, Sophie Paczesny, Stefanie Sarantopoulos  Biology of Blood and Marrow Transplantation  Volume 18, Issue 1, Pages S116-S124 (January 2012) DOI: /j.bbmt Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Biomarker research steps.
Biology of Blood and Marrow Transplantation  , S116-S124DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Biologically relevant BAFF and B cell markers in plasma, blood, and bone marrow. (A) Naive and transitional B cells are increased in patients without cGVHD, and these may serve as predictive markers of good post-HSCT health. (B) Low transitional and naive B cell numbers and high BAFF/B cell ratios may serve as markers of cGVHD. Biology of Blood and Marrow Transplantation  , S116-S124DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Possible randomized, double-blinded, placebo-controlled, trial design to test GVHD preemption. Biology of Blood and Marrow Transplantation  , S116-S124DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions


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