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Placental Transmogrification of the Lung Presenting as a Small Solitary Nodule  Yuichi Saito, MD, Tomohiko Ikeya, MD, PhD, Eishin Hoshi, MD, PhD, Nobumasa.

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Presentation on theme: "Placental Transmogrification of the Lung Presenting as a Small Solitary Nodule  Yuichi Saito, MD, Tomohiko Ikeya, MD, PhD, Eishin Hoshi, MD, PhD, Nobumasa."— Presentation transcript:

1 Placental Transmogrification of the Lung Presenting as a Small Solitary Nodule 
Yuichi Saito, MD, Tomohiko Ikeya, MD, PhD, Eishin Hoshi, MD, PhD, Nobumasa Takahashi, MD, PhD, Katsumi Murai, MD, PhD, Yoshinori Kawabata, MD, PhD, Thomas V. Colby, MD, PhD  The Annals of Thoracic Surgery  Volume 87, Issue 3, Pages (March 2009) DOI: /j.athoracsur Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 High-resolution computed tomographic scan shows an only 10-mm nodule containing several round-shaped air spaces like footballs without bullous emphysema in the right lower lobe. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 (A) Histologic examination shows villous structure resembling placental chorionic villi with destruction of the lung. The core is various from cellular to fibrous (Hematoxylin and eosin; ×2.) (B) The cellular core of villous structure is mainly composed of clear cells (Hematoxylin and eosin; ×40.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 (A) At the border of the villous structure, the cellular core containing clear cells continues to normal lung tissue. (Hematoxylin and eosin; ×40.) (B) Immunohistochemistry; epithelial membrane antigen is expressed by type 2 cells (Hematoxylin and eosin; ×40.) (C) Clear cells are positive for CD10 (Hematoxylin and eosin; ×40.) (D) Flat cells on the vascular space are positive for D2-40 (Hematoxylin and eosin; ×40.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

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