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Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia  Giuseppe R Nigri, MD, PhD, Sylvie.

Published byВадим Пашков Modified over 5 years ago

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Presentation on theme: "Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia  Giuseppe R Nigri, MD, PhD, Sylvie."— Presentation transcript:

1 Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia  Giuseppe R Nigri, MD, PhD, Sylvie Kossodo, PhD, Peter Waterman, BS, Patrick Fungaloi, MD, Glenn M LaMuraglia, MD  Journal of Vascular Surgery  Volume 39, Issue 4, Pages (April 2004) DOI: /j.jvs

2 Fig 1 Histologic section demonstrates lack of a continuous endothelial layer and numerous neutrophils (N) adhering to the intimal surface of the graft in the control group 24 hours after surgery. Inflammatory cell infiltrate in the vessel wall is moderate. Occasional neutrophils are present in the adventitial layer of the vein graft (A) (hematoxylin-eosin; original magnification ×200). Bar represents 100 μm. Journal of Vascular Surgery  , DOI: ( /j.jvs )

3 Fig 2 Area of vein graft in the control group demonstrates most consistent intimal hyperplasia (IH) is just proximal to the distal anastomosis; this area was used for morphometric analysis. Numerous neutrophils are present in the adventitia (A) (hematoxylin-eosin; original magnification ×100). Bar represents 100 μm. Journal of Vascular Surgery  , DOI: ( /j.jvs )

4 Fig 3 After 2 weeks, histologic section shows lack of intimal hyperplasia in the deferoxamine–photodynamic therapy group (DFX-PDT) group. In addition, partial reendothelialization (E) is observed. Only rare neutrophils are present in the adventitia (A) (hematoxylin-eosin; original magnification ×200). Bar represents 100 μm. Journal of Vascular Surgery  , DOI: ( /j.jvs )

5 Fig 4 Morphometric analysis reveals significant reduction in intimal hyperplasia in the group treated with deferoxamine and photodynamic therapy (DFX-PDT) (*P < .002 compared with control groups C and C-DFX), with 91% intimal area reduction (A) and 35% medial area reduction (B). C, Lumen diameter is not significantly reduced. Journal of Vascular Surgery  , DOI: ( /j.jvs )

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