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Tumorlets in Familial History of Bronchopulmonary Carcinoid

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Presentation on theme: "Tumorlets in Familial History of Bronchopulmonary Carcinoid"— Presentation transcript:

1 Tumorlets in Familial History of Bronchopulmonary Carcinoid
Ugo De Giorgi, MD, Francesca Fanini, BS, Dino Amadori, MD, Alessandra Cancellieri, MD, Giammaria Fiorentini, MD, Venerino Poletti, MD, Luisa Barzon, MD, Giulia Masi, MD  Journal of Thoracic Oncology  Volume 6, Issue 9, Pages (September 2011) DOI: /JTO.0b013e318221f54f Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Histopathological evaluation of the tumor after upper right lobectomy showed the presence of neoplastic cells with abundant, eosinophilic cytoplasms and vesicular nuclei, slight atypia, and sparse mitotic figures (<2/10 HPF). Journal of Thoracic Oncology 2011 6, DOI: ( /JTO.0b013e318221f54f) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Histopathological evaluation of multiple bronchoscopic biopsies revealed multiple subepithelial neuroendocrine glandular proliferations with nests, cords, and pseudoglandular structures composed of tumor cells with abundant cytoplasms. Journal of Thoracic Oncology 2011 6, DOI: ( /JTO.0b013e318221f54f) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Direct sequencing of exon 9 of the MEN1 gene amplified from (A) genomic DNA, showing the heterozygous D418D C to T transition (arrow), and (B) tumorlet DNA from the same patient, showing loss of heterozygosity (arrow). Journal of Thoracic Oncology 2011 6, DOI: ( /JTO.0b013e318221f54f) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

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