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Methodologic issues in clinical trials for prevention or risk reduction in osteoarthritis  J.M. Jordan, M.F. Sowers, S.P. Messier, J. Bradley, G. Arangio,

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Presentation on theme: "Methodologic issues in clinical trials for prevention or risk reduction in osteoarthritis  J.M. Jordan, M.F. Sowers, S.P. Messier, J. Bradley, G. Arangio,"— Presentation transcript:

1 Methodologic issues in clinical trials for prevention or risk reduction in osteoarthritis 
J.M. Jordan, M.F. Sowers, S.P. Messier, J. Bradley, G. Arangio, J.N. Katz, E. Losina, L. Rovati, N. Bachtell, C. Cooper, T. Spector, W. Zhang, J. Gardiner, M. Wahba  Osteoarthritis and Cartilage  Volume 19, Issue 5, Pages (May 2011) DOI: /j.joca Copyright © Terms and Conditions

2 Fig. 1 Structural abn’l=structural abnormality.
Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Fig. 2 Three-year transition probabilities of K–L score of 1 (doubtful OA) staying at a K–L=1 or progressing to a K–L=2 to OA as a function of age (years) and BMI (kg/m2): designing a prevention trial of knee OA. (A) Transition probability of K–L=1 score staying at K–L=1; (B) Transition probability of K–L=1 score to a K–L=2 score, indicative of OA. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © Terms and Conditions


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