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Gross pathology and histopathology of asthma

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1 Gross pathology and histopathology of asthma
Qutayba Hamid, PhD, Editor  Journal of Allergy and Clinical Immunology  Volume 111, Issue 2, Pages (February 2003) DOI: /mai Copyright © 2003 Mosby, Inc. Terms and Conditions

2 Fig. 1 Biopsy from the proximal airways of a normal, nonasthmatic subject shows an intact epithelium containing a small number of goblet cells and inflammatory cells in the submucosa. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

3 Fig. 1 Biopsy from the proximal airways of a normal, nonasthmatic subject shows an intact epithelium containing a small number of goblet cells and inflammatory cells in the submucosa. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

4 Fig. 2 Cross section of a small airway (<2 mm in diameter) shows an intact epithelium that is lined by cuboidal cells and a thin layer of smooth muscle around the airway. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

5 Fig. 2 Cross section of a small airway (<2 mm in diameter) shows an intact epithelium that is lined by cuboidal cells and a thin layer of smooth muscle around the airway. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

6 Fig. 3 Section from the proximal airway of a patient who died of status asthmaticus shows many of the classic pathologic changes described in asthma. In particular, note the eosinophilic plug, a detached epithelium, subepithelium, thickening, smooth muscle hyperplasia/hypertrophy, and the marked inflammatory infiltrate. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

7 Fig. 3 Section from the proximal airway of a patient who died of status asthmaticus shows many of the classic pathologic changes described in asthma. In particular, note the eosinophilic plug, a detached epithelium, subepithelium, thickening, smooth muscle hyperplasia/hypertrophy, and the marked inflammatory infiltrate. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

8 Fig. 4 Gross pathology of lung of asthmatic patient who died of status asthmaticus. There are notable hemorrhagic changes, edema, and hyperinflation from obstruction of the small airways. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

9 Fig. 4 Gross pathology of lung of asthmatic patient who died of status asthmaticus. There are notable hemorrhagic changes, edema, and hyperinflation from obstruction of the small airways. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

10 Fig. 5 Endoscopic biopsy from a patient with chronic moderate asthma shows partial epithelial detachment and hypertrophy of smooth muscle layer with close approximation to the epithelium. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

11 Fig. 5 Endoscopic biopsy from a patient with chronic moderate asthma shows partial epithelial detachment and hypertrophy of smooth muscle layer with close approximation to the epithelium. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

12 Fig. 6 Endoscopic biopsy from a patient with severe asthma shows mucus hyperplasia, extensive thickening of the subepithelial layer and marked infiltration of inflammatory cells—in particular, eosinophils. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

13 Fig. 6 Endoscopic biopsy from a patient with severe asthma shows mucus hyperplasia, extensive thickening of the subepithelial layer and marked infiltration of inflammatory cells—in particular, eosinophils. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

14 Fig. 7 Cross section of a small airway from a patient who died of complications from severe chronic asthma shows extensive airway remodeling of the small airways with increased smooth muscle mass and collagen deposition. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

15 Fig. 7 Cross section of a small airway from a patient who died of complications from severe chronic asthma shows extensive airway remodeling of the small airways with increased smooth muscle mass and collagen deposition. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

16 Fig. 8 Cross section of a small airway from a patient with chronic severe asthma shows eosinophilic infiltrate in the submucosa and in the area of the smooth muscle. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

17 Fig. 8 Cross section of a small airway from a patient with chronic severe asthma shows eosinophilic infiltrate in the submucosa and in the area of the smooth muscle. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

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