4. Limb skeletal phenotypes of Prx1cre;Twist1 and Twist1Ska10/Ska10 mutants.
Limb skeletal phenotypes of Prx1cre;Twist1 and Twist1Ska10/Ska10 mutants. (A-N) Skeleton preparations of mouse P1 forelimbs (A-H) and hindlimbs (I-N). Upper panel in D shows an example of a mutant forelimb lacking radius, whereas the lower panel shows an example of a mutant forelimb with radius-to-ulna transformation. The boxed regions in A,D are enlarged in B,E, respectively. Arrowheads indicate the olecranon process as a feature unique to the ulna (B,E), or a tri-phalanx anterior digit (H,L). Arrows (D,G,K,M) indicate the presence of only the posterior element in the zeugopod. Asterisks (L,N) indicate bifurcated digits. The autopod-only views in all figures are oriented with anterior to the left.
Zhang Z et al. Development 2010;137: